Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2908230 | 0.91 | ITGA4 (0.41) | ITGA4L3MBTL1SMN1; SMN2MAPTLMNA | |
| SCHEMBL2909532 | 0.88 | NR1H4 (0.39) | ITGA4L3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2913787 | 0.88 | KIF18A (0.39) | MAPTTSHRHSD17B10 | |
| SCHEMBL1530730 | 0.85 | NPC1 (0.40) | L3MBTL1SMN1; SMN2NPC1RAB9ASCARB1 | |
| SCHEMBL2913182 | 0.84 | NR1H4 (0.36) | ITGA4L3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2915115 | 0.84 | BCL2 (0.37) | ITGA4L3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2915751 | 0.84 | NR1H4 (0.34) | SMN1; SMN2NPC1RAB9ASCARB1MAPT | |
| SCHEMBL2907824 | 0.81 | MAPT (0.39) | ITGA4L3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2915481 | 0.81 | NR1H4 (0.41) | ITGA4L3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2913384 | 0.80 | NR1H4 (0.40) | ITGA4L3MBTL1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |