Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12186234 | 1.00 | TSHR (0.39) | TSHRCYP1A2MAPK1 | |
| SCHEMBL31164268 | 1.00 | TSHR (0.39) | TSHRCYP1A2MAPK1 | |
| SCHEMBL3016069 | 1.00 | TSHR (0.39) | TSHRCYP1A2MAPK1 | |
| SCHEMBL4740330 | 0.83 | TSHR (0.41) | TSHRCYP1A2MAPK1 | |
| Ammonia Solution, Strong SCHEMBL27805104 | 0.80 | TSHR (0.39) | TSHRCYP1A2MAPK1 | |
| SCHEMBL27903049 | 0.77 | PLA2G10 (0.38) | CYP1A2 | |
| SCHEMBL22613723 | 0.77 | TSHR (0.32) | TSHR | |
| SCHEMBL819717 | 0.77 | TSHR (0.33) | TSHR | |
| SCHEMBL68459 | 0.76 | — | — | |
| SCHEMBL268075 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 140 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118666698-A | Preparation method of pregabalin | 浙江普洛家园药业有限公司 | 2024-09-20 | — | — | CN | claimed |
| CN-118421609-A | Immobilized nitrilase for synthesizing pregabalin chiral intermediate, and preparation method and application thereof | 浙江普洛家园药业有限公司 | 2024-08-02 | — | — | CN | claimed |
| CN-118421720-A | Synthesis method of (S) -3-cyano-5-methylhexanoic acid | 浙江普洛家园药业有限公司 | 2024-08-02 | — | — | CN | claimed |
| CN-117165563-A | Immobilization method of nitrilase | 浙江工业大学 | 2023-12-05 | — | — | CN | claimed |
| CN-112852790-B | Plant nitrilase chimeric enzyme mutant, coding gene and application thereof | 浙江工业大学 | 2022-04-29 | — | — | CN | claimed |
| CN-112626057-B | Chimeric plant nitrilase mutant, coding gene and application thereof | 浙江工业大学 | 2022-03-08 | — | — | CN | claimed |
| CN-113651717-A | Racemization method of optically pure isobutyl succinonitrile | 浙江工业大学 | 2021-11-16 | — | — | CN | claimed |
| CN-112852790-A | Plant nitrilase chimeric enzyme mutant, coding gene and application thereof | 浙江工业大学 | 2021-05-28 | — | — | CN | claimed |
| CN-112626057-A | Chimeric plant nitrilase mutant, coding gene and application thereof | 浙江工业大学 | 2021-04-09 | — | — | CN | claimed |
| CN-110714002-B | Plant nitrilase mutant, coding gene and application thereof | 浙江工业大学 | 2021-03-26 | — | — | CN | claimed |
| US-8304252-B2 | Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids | PFIZER INC. (US) | 2012-11-06 | — | — | US | claimed |
| US-20100204503-A1 | Stereoselective Bioconversion of Aliphatic Dinitriles into Cyano Carboxylic Acids | PFIZER INC | 2010-08-12 | — | — | US | claimed |
| US-7727749-B2 | Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids | PFIZER, INC. (US) | 2010-06-01 | — | — | US | claimed |
| CN-1942587-B | Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids | PFIZER PROD INC | 2010-05-05 | — | — | CN | claimed |
| EP-1745136-B1 | METHOD FOR ENZYMATIC PREPARATION OF (S)-3-CYANO-5-METHYLHEXANOIC ACID | PFIZER PROD INC (US) | 2009-10-07 | — | — | EP | claimed |
| US-20070196905-A1 | Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids | PFIZER INC. | 2007-08-23 | — | — | US | claimed |
| CN-1942587-A | Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids | PFIZER PROD INC (US) | 2007-04-04 | — | — | CN | claimed |
| EP-1745136-A1 | STEREOSELECTIVE BIOCONVERSION OF ALIPHATIC DINITRILES INTO CYANO CARBOXYLIC ACIDS | Pfizer Products Inc. (US) | 2007-01-24 | — | — | EP | claimed |
| WO-2005100580-A1 | STEREOSELECTIVE BIOCONVERSION OF ALIPHATIC DINITRILES INTO CYANO CARBOXYLIC ACIDS | PFIZER PRODUCTS INC. (US) | 2005-10-27 | — | — | WO | claimed |
| US-4123438-A | Process for preparing 2-pyrrolidones | STAMICARBON, B.V. (NL) | 1978-10-31 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070196905-A1 | Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids | GABRD, GABRB3, GABRB2 | TSHR 4626/4885CYP1A2 306/4885MAPK1 4175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.