Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 8/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.51 |
| ▸ | MTOR | P42345 | 2/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30425346 | 0.80 | INSR (0.50) | FYNINSRALKLRRK2CHEK1 | |
| SCHEMBL1493621 | 0.80 | INSR (0.50) | FYNINSRALKLRRK2CHEK1 | |
| SCHEMBL2558872 | 0.79 | DHFR (0.60) | DHFRPIK3CAMTORFYNCDK1 | |
| SCHEMBL2952943 | 0.76 | MAP2K7 (0.45) | PIK3CAFYNINSRALKLRRK2 | |
| SCHEMBL4611806 | 0.76 | DHFR (0.71) | DHFRPIK3CA | |
| SCHEMBL4101304 | 0.74 | LRRK2 (0.44) | INSRALKLRRK2CDK1CDK2 | |
| SCHEMBL1230791 | 0.74 | PTK2 (0.48) | PIK3CAMTORFYNINSRALK | |
| SCHEMBL223337 | 0.74 | LGMN (0.61) | FYNINSRALKLRRK2CHEK1 | |
| Hydrochloric Acid SCHEMBL3402782 | 0.73 | LGMN (0.59) | FYNINSRALKLRRK2CHEK1 | |
| Hydrochloric Acid SCHEMBL375344 | 0.73 | LGMN (0.59) | FYNINSRALKLRRK2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |