Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2922367 | 0.81 | RAB9A (0.47) | ALDH1A1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2917155 | 0.81 | AURKA (0.50) | ALDH1A1HPGDTDP1KMT2ARAB9A | |
| SCHEMBL2922370 | 0.73 | AURKA (0.68) | RAB9ANPC1AURKACCNA2CDK2 | |
| SCHEMBL2921958 | 0.67 | CCNA2 (0.65) | ALDH1A1HPGDKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL2916029 | 0.65 | CCNA2 (0.41) | ALDH1A1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2921266 | 0.65 | CCNA2 (0.63) | HPGDKMT2ARAB9ANPC1AURKA | |
| SCHEMBL5123738 | 0.65 | ALDH1A1 (0.77) | ALDH1A1HPGDKMT2ARAB9ANPC1 | |
| SCHEMBL5720799 | 0.64 | CCNA2 (0.47) | SMN1; SMN2AURKACCNA2CDK2CCNA1 | |
| SCHEMBL13074753 | 0.63 | ALDH1A1 (0.64) | ALDH1A1HPGDKMT2ARAB9ANPC1 | |
| SCHEMBL16266238 | 0.63 | ALDH1A1 (1.00) | ALDH1A1HPGDTDP1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320531-B1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2010-09-08 | — | — | EP | claimed |