Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.50 |
| ▸ | CDK2 | P24941 | 8/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2922370 | 0.81 | AURKA (0.68) | AURKACCNA2CDK2CCNA1RAB9A | |
| SCHEMBL2917150 | 0.81 | ALDH1A1 (0.44) | AURKACCNA2CDK2CCNA1ALDH1A1 | |
| SCHEMBL2922367 | 0.73 | RAB9A (0.47) | AURKACCNA2CDK2CCNA1ALDH1A1 | |
| SCHEMBL12057908 | 0.70 | AURKA (0.68) | AURKACCNA2CDK2CCNA1ALDH1A1 | |
| SCHEMBL2921962 | 0.67 | CDK2 (1.00) | AURKACCNA2CDK2CCNA1 | |
| SCHEMBL19358427 | 0.66 | SMN1; SMN2 (0.52) | AURKACCNA2CDK2CCNA1TDP1 | |
| SCHEMBL17229680 | 0.66 | CCNA2 (0.48) | AURKACCNA2CDK2CCNA1 | |
| SCHEMBL19358472 | 0.65 | NAMPT (0.38) | AURKACCNA2CDK2CCNA1 | |
| SCHEMBL2916033 | 0.65 | AURKA (0.65) | AURKACCNA2CDK2CCNA1 | |
| SCHEMBL2921269 | 0.65 | AURKA (1.00) | AURKACCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320531-B1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2010-09-08 | — | — | EP | claimed |