Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.36 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | EML4 | Q9HC35 | 5/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 4/20 | 0.34 |
| ▸ | ETV6 | P41212 | 3/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 5/20 | 0.33 |
| ▸ | ROS1 | P08922 | 5/20 | 0.33 |
| ▸ | FLT3 | P36888 | 5/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL30205745 | 1.00 | SYK (0.36) | SYKCCNCCDK8EML4ALK | |
| SCHEMBL24943841 | 0.97 | SYK (0.38) | SYKCCNCCDK8EML4ALK | |
| SCHEMBL30206281 | 0.91 | HRH3 (0.37) | SYKCCNCCDK8FGFR3HRH3 | |
| SCHEMBL29173651 | 0.91 | HRH3 (0.37) | SYKCCNCCDK8FGFR3HRH3 | |
| SCHEMBL30206332 | 0.89 | FGFR3 (0.39) | SYKCCNCCDK8FGFR3HRH3 | |
| SCHEMBL29173450 | 0.89 | FGFR3 (0.39) | SYKCCNCCDK8FGFR3HRH3 | |
| SCHEMBL30205579 | 0.89 | SYK (0.44) | SYKCCNCCDK8EML4ALK | |
| SCHEMBL24944183 | 0.89 | SYK (0.44) | SYKCCNCCDK8EML4ALK | |
| SCHEMBL24944792 | 0.85 | CAMK2D (0.40) | SYKCCNCCDK8EML4ALK | |
| SCHEMBL30205550 | 0.85 | CAMK2D (0.40) | SYKCCNCCDK8EML4ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |