Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 3/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29173651 | 1.00 | HRH3 (0.37) | HRH3FGFR3CCNCCDK8HIF1A | |
| SCHEMBL24943841 | 0.93 | SYK (0.38) | HRH3FGFR3CCNCCDK8HIF1A | |
| SCHEMBL29173450 | 0.93 | FGFR3 (0.39) | HRH3FGFR3CCNCCDK8HIF1A | |
| SCHEMBL30206332 | 0.93 | FGFR3 (0.39) | HRH3FGFR3CCNCCDK8HIF1A | |
| Formic Acid SCHEMBL30205745 | 0.91 | SYK (0.36) | HRH3FGFR3CCNCCDK8HIF1A | |
| Formic Acid SCHEMBL29173273 | 0.91 | SYK (0.36) | HRH3FGFR3CCNCCDK8HIF1A | |
| SCHEMBL31577289 | 0.88 | HRH3 (0.36) | HRH3FGFR3CCNCCDK8SYK | |
| SCHEMBL29173582 | 0.86 | PIM1 (0.41) | SYKFLT3AURKACDK2 | |
| SCHEMBL29173539 | 0.86 | SYK (0.41) | SYK | |
| SCHEMBL31577217 | 0.84 | FLT3 (0.33) | HRH3FGFR3CCNCCDK8HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2024-05-29 | — | — | EP | disclosed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |