Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL30205522 | 1.00 | AURKA (0.33) | AURKARPS6KB1AURKBEML4ALK | |
| SCHEMBL24944974 | 0.97 | ALK (0.34) | AURKARPS6KB1AURKBEML4ALK | |
| SCHEMBL30205499 | 0.88 | TYK2 (0.37) | EML4ALKSYK | |
| SCHEMBL24944982 | 0.88 | TYK2 (0.37) | EML4ALKSYK | |
| SCHEMBL29173658 | 0.88 | BUB1 (0.34) | SYKHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL24943808 | 0.86 | EML4 (0.33) | AURKARPS6KB1AURKBEML4ALK | |
| SCHEMBL30205492 | 0.86 | EML4 (0.33) | AURKARPS6KB1AURKBEML4ALK | |
| SCHEMBL30206306 | 0.85 | EML4 (0.33) | EML4ALKSYK | |
| Hydrochloric Acid SCHEMBL30206015 | 0.84 | EML4 (0.33) | EML4ALKSYK | |
| SCHEMBL24943828 | 0.84 | CDK2 (0.37) | AURKAAURKBSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |