Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 5/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.40 |
| ▸ | CDK1 | P06493 | 3/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.40 |
| ▸ | CDK9 | P50750 | 3/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29174718 | 0.73 | EGFR (0.57) | JAK2JAK1JAK3CDK2CCNE1 | |
| SCHEMBL29174688 | 0.73 | HDAC3 (0.47) | JAK2JAK1JAK3CDK2CCNE2 | |
| SCHEMBL30725499 | 0.73 | HDAC3 (0.47) | JAK2JAK1JAK3CDK2CCNE2 | |
| SCHEMBL30725463 | 0.72 | ALDH1A1 (0.42) | CDK2CCNE2CCNE1TGFBR1TGFBR2 | |
| SCHEMBL29174633 | 0.72 | ALDH1A1 (0.42) | CDK2CCNE2CCNE1TGFBR1TGFBR2 | |
| SCHEMBL29174698 | 0.70 | MEN1 (0.47) | JAK2JAK3CDK2CCNE2CCNE1 | |
| SCHEMBL22098063 | 0.70 | JAK2 (0.47) | JAK2JAK1JAK3FLT4KDR | |
| SCHEMBL25328688 | 0.69 | EGFR (0.63) | JAK2JAK1CDK2CCNE1KDR | |
| SCHEMBL25329789 | 0.68 | JAK2 (0.43) | JAK2JAK1JAK3CDK2CCNE2 | |
| SCHEMBL30956630 | 0.68 | FLT4 (0.48) | JAK2JAK1JAK3FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117430589-A | 2-aminopyrimidine compound or salt thereof, and preparation method and application thereof | 励缔(杭州)医药科技有限公司 | 2024-01-23 | — | — | CN | disclosed |