Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL711049 | 0.77 | HSP90AB1 (0.50) | POLBMAPTGAAALDH1A1KMT2A | |
| SCHEMBL29174586 | 0.71 | POLB (0.49) | POLBLOXL2L3MBTL1CA12CA1 | |
| SCHEMBL11039825 | 0.70 | POLB (0.61) | POLBLOXL2CA12CA1CA2 | |
| SCHEMBL8087428 | 0.70 | POLB (0.76) | POLBLOXL2CA12CA1CA2 | |
| SCHEMBL44366 | 0.70 | POLB (0.76) | POLBLOXL2CA12CA1CA2 | |
| SCHEMBL8094050 | 0.70 | POLB (0.76) | POLBLOXL2CA12CA1CA2 | |
| SCHEMBL27903182 | 0.70 | MAPT (0.51) | POLBLOXL2KCNJ1KCNH2MAPT | |
| SCHEMBL2917313 | 0.69 | ALDH1A1 (0.75) | POLBLOXL2CA12CA1CA2 | |
| SCHEMBL4833237 | 0.69 | ALDH1A1 (0.49) | POLBLOXL2KCNJ1KCNH2MAPT | |
| SCHEMBL11045904 | 0.68 | POLB (0.67) | POLBLOXL2L3MBTL1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117430589-A | 2-aminopyrimidine compound or salt thereof, and preparation method and application thereof | 励缔(杭州)医药科技有限公司 | 2024-01-23 | — | — | CN | disclosed |