Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 5/20 | 0.34 |
| ▸ | CDK7 | P50613 | 4/20 | 0.34 |
| ▸ | CCNH | P51946 | 4/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23529884 | 0.78 | XDH (0.36) | CDK2CDK7CCNHMNAT1CCNE1 | |
| SCHEMBL18510365 | 0.77 | CDK7 (0.34) | CDK2CDK7CCNHMNAT1CCNE1 | |
| SCHEMBL24408250 | 0.77 | HAVCR2 (0.35) | CDK2CDK7CCNHMNAT1CCNE1 | |
| SCHEMBL15224509 | 0.74 | LMNA (0.36) | LMNACDK2CDK7CCNHMNAT1 | |
| SCHEMBL21741564 | 0.73 | CDK2 (0.39) | CDK2CDK7CCNHMNAT1CCNE1 | |
| SCHEMBL29174908 | 0.69 | CDK2 (0.36) | CDK2CDK7CCNHMNAT1CCNE1 | |
| SCHEMBL29174808 | 0.68 | ALDH1A1 (0.41) | MAPK1SMN1; SMN2CDK2CDK7CCNH | |
| SCHEMBL29174891 | 0.68 | ALDH1A1 (0.44) | LMNAMAPK1SMN1; SMN2CDK2CDK7 | |
| SCHEMBL18520998 | 0.67 | ALDH1A1 (0.39) | ADORA1ADORA2AADORA2BADORA3CYP1A2 | |
| SCHEMBL24236930 | 0.67 | HTR2C (0.31) | HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240270750-A1 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2024-08-15 | — | — | US | disclosed |
| EP-4346806-A2 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | Biocryst Pharmaceuticals, Inc. (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-117529315-A | Imidazole-containing ALK2 kinase inhibitors | 生物水晶制药公司 | 2024-02-06 | — | — | CN | disclosed |
| WO-2022251188-A2 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | BIOCRYST PHARMACEUTICALS, INC. (US) | 2022-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240270750-A1 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | ALK, ACVR2B, ACVR2A | HTR2C 3935/4885TYK2 205/4885ADORA1 3027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.