Known targets — ChEMBL curated mechanism
DRD1DRD2DRD3DRD4DRD5SLC6A2SLC6A4
The experimentally established mechanism targets of Amoxapine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 8/20 | 0.98 |
| ▸ | DRD4 known ✓ | P21917 | 5/20 | 0.98 |
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 0.98 |
| ▸ | DRD1 known ✓ | P21728 | 3/20 | 0.98 |
| ▸ | DRD5 known ✓ | P21918 | 2/20 | 0.98 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.98 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.98 |
| ▸ | HTR1A | P08908 | 3/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.98 |
| ▸ | HTR2A | P28223 | 3/20 | 0.98 |
| ▸ | HRH2 | P25021 | 3/20 | 0.98 |
| ▸ | HRH1 | P35367 | 3/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.98 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.98 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.98 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amoxapine SCHEMBL29354942 | 0.99 | DRD2 (1.00) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL5498936 | 0.99 | DRD2 (1.00) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL29370074 | 0.99 | DRD2 (1.00) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL29482386 | 0.99 | DRD2 (1.00) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL33950 | 0.99 | DRD2 (1.00) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL8741185 | 0.95 | DRD2 (0.93) | DRD2DRD4CHRM1DRD3HTR1A | |
| SCHEMBL2738976 | 0.89 | DRD4 (0.82) | DRD2DRD4CHRM1DRD3HTR1A | |
| SCHEMBL3409689 | 0.88 | DRD2 (0.80) | DRD2DRD4CHRM1DRD3HTR1A | |
| SCHEMBL25410757 | 0.86 | HRH4 (0.77) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL21225243 | 0.86 | DRD2 (0.76) | DRD2DRD4CHRM1DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114846012-B | 2-isoindole-1, 3, 4-oxadiazole derivatives useful as HDAC6 inhibitors | 武田药品工业株式会社 | 2024-01-26 | — | — | CN | disclosed |