Known targets — ChEMBL curated mechanism
DRD1DRD2DRD3DRD4DRD5SLC6A2SLC6A4
The experimentally established mechanism targets of Amoxapine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 8/20 | 1.00 |
| ▸ | DRD4 known ✓ | P21917 | 5/20 | 1.00 |
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 1.00 |
| ▸ | DRD1 known ✓ | P21728 | 3/20 | 1.00 |
| ▸ | DRD5 known ✓ | P21918 | 2/20 | 1.00 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 1.00 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 5/20 | 1.00 |
| ▸ | HTR1A | P08908 | 3/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 3/20 | 1.00 |
| ▸ | HTR2A | P28223 | 3/20 | 1.00 |
| ▸ | HRH2 | P25021 | 3/20 | 1.00 |
| ▸ | HRH1 | P35367 | 3/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 3/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 3/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 3/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 3/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amoxapine SCHEMBL29370074 | 1.00 | DRD2 (1.00) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL29482386 | 1.00 | DRD2 (1.00) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL5498936 | 1.00 | DRD2 (1.00) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL29354942 | 1.00 | DRD2 (1.00) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL29180215 | 0.99 | DRD2 (0.98) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL8741185 | 0.96 | DRD2 (0.93) | DRD2DRD4CHRM1DRD3HTR1A | |
| SCHEMBL2738976 | 0.90 | DRD4 (0.82) | DRD2DRD4CHRM1DRD3HTR1A | |
| SCHEMBL3409689 | 0.89 | DRD2 (0.80) | DRD2DRD4CHRM1DRD3HTR1A | |
| SCHEMBL25410757 | 0.87 | HRH4 (0.77) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL21225243 | 0.87 | DRD2 (0.76) | DRD2DRD4CHRM1DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 21698 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| CN-122036817-A | C-alkyl carbon glycoside and preparation method thereof | 江西师范大学 | 2026-05-15 | — | — | CN | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| US-12624037-B2 | Method of treating agitation, aggressive behavior, and impulse control disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| US-12624036-B2 | Method of treating post-traumatic stress disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| US-12617809-B2 | Cardioprotective lipid and method of use | SIGNPATH PHARMA, INC. (US) | 2026-05-05 | — | — | US | claimed |
| US-20260108493-A1 | COMPOSITIONS COMPRISING A SEROTONERGIC TRYPTAMINE COMPOUND | CAAMTECH, INC. (US) | 2026-04-23 | — | — | US | claimed |
| US-20260083709-A1 | COMBINATION PHARMACOLOGICAL INTERVENTIONS FOR MULTIPLE MECHANISMS OF OBSTRUCTIVE SLEEP APNEA | APNIMED INC DELAWARE (US) | 2026-03-26 | — | — | US | claimed |
| EP-4706649-A1 | USE OF ADRENALIN FOR THE TREATMENT OF SHOCKS | BIOPROJET (FR) | 2026-03-11 | — | — | EP | claimed |
| US-12544385-B2 | Combination drug therapies for CNS disorders | JAVED MOHAMMAD (US) | 2026-02-10 | — | — | US | claimed |
| WO-1994020100-A1 | METHOD FOR TREATING EMOTIONAL OR MENTAL ILLNESS AND EMOTIONAL OR MENTAL ILLNESS CONCOMITANT WITH SEIZURES | NAGLE, JOHN, S. (US) | 1994-09-15 | — | — | WO | claimed |
| US-5308768-A | Detection of cortisols, cortisone and corticosterone | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1994-05-03 | — | — | US | claimed |
| US-4977145-A | ADMINISTERING ANGIOTENSIN CONVERTING ENZYME INHIBITOR AND ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1990-12-11 | — | — | US | claimed |
| EP-0174342-B1 | BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES | UNIVERSITY OF FLORIDA (US) | 1989-12-20 | — | — | EP | claimed |
| EP-0334889-A4 | COMPOSITION FOR TREATING OBESITY. | SEROTONIN IND (US) | 1989-10-27 | — | — | EP | claimed |
| EP-0334889-A1 | COMPOSITION FOR TREATING OBESITY. | SEROTONIN IND (US) | 1989-10-04 | — | — | EP | claimed |
| US-4843071-A | NOREPINEPHRINE PRECURSOR AND RE-UPTAKE INHIBITOR | SEROTONIN INDUSTRIES OF CHARLESTON (US) | 1989-06-27 | — | — | US | claimed |
| WO-1988004173-A1 | METHOD AND COMPOSITION FOR TREATING OBESITY, DEPRESSION, DRUG ABUSE, AND NARCOLEPSY | SEROTONIN INDUSTRIES OF CHARLESTON (US) | 1988-06-16 | — | — | WO | claimed |
| US-4169707-A | Process for treatment of yarn within a steaming chamber | ETABLISSEMENTS SUPERBA S.A. (FR) | 1979-10-02 | — | — | US | claimed |
| US-4016273-A | Sustained release forms of certain oxazepines for parenteral administration | AMERICAN CYANAMID COMPANY (US) | 1977-04-05 | — | — | US | claimed |