Known targets — ChEMBL curated mechanism
DRD1DRD2DRD3DRD4DRD5SLC6A2SLC6A4
The experimentally established mechanism targets of Amoxapine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 8/20 | 1.00 |
| ▸ | DRD4 known ✓ | P21917 | 5/20 | 1.00 |
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 1.00 |
| ▸ | DRD1 known ✓ | P21728 | 3/20 | 1.00 |
| ▸ | DRD5 known ✓ | P21918 | 2/20 | 1.00 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 1.00 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 5/20 | 1.00 |
| ▸ | HTR1A | P08908 | 3/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 3/20 | 1.00 |
| ▸ | HTR2A | P28223 | 3/20 | 1.00 |
| ▸ | HRH2 | P25021 | 3/20 | 1.00 |
| ▸ | HRH1 | P35367 | 3/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 3/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 3/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 3/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 3/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amoxapine SCHEMBL29482386 | 1.00 | DRD2 (1.00) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL5498936 | 1.00 | DRD2 (1.00) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL29354942 | 1.00 | DRD2 (1.00) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL33950 | 1.00 | DRD2 (1.00) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL29180215 | 0.99 | DRD2 (0.98) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL8741185 | 0.96 | DRD2 (0.93) | DRD2DRD4CHRM1DRD3HTR1A | |
| SCHEMBL2738976 | 0.90 | DRD4 (0.82) | DRD2DRD4CHRM1DRD3HTR1A | |
| SCHEMBL3409689 | 0.89 | DRD2 (0.80) | DRD2DRD4CHRM1DRD3HTR1A | |
| SCHEMBL25410757 | 0.87 | HRH4 (0.77) | DRD2DRD4CHRM1DRD3HTR1A | |
| Amoxapine SCHEMBL21225243 | 0.87 | DRD2 (0.76) | DRD2DRD4CHRM1DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116109155-B | Method and device for evaluating longitudinal connectivity of dam-built river | 中国长江三峡集团有限公司 | 2025-03-07 | — | — | CN | claimed |
| CN-119527997-A | Escalator load dynamic monitoring method and system | 吴晓军 | 2025-02-28 | — | — | CN | claimed |
| CN-119069126-A | Postpartum anemia risk prediction model and application method thereof | 汤臣倍健股份有限公司 | 2024-12-03 | — | — | CN | claimed |
| CN-114020730-B | Method for detecting and repairing abnormal value in water environment monitoring data | 河北科技师范学院 | 2024-09-13 | — | — | CN | claimed |
| CN-118092526-A | Safety regulation control system for music performance stage equipment | 黑河学院 | 2024-05-28 | — | — | CN | claimed |
| CN-112162694-B | Data transmission speed control method and device | 合肥中科君达视界技术股份有限公司 | 2024-05-07 | — | — | CN | claimed |
| CN-116049686-A | Railway direct-current relay running state evaluation method based on distance measurement | 沈阳工业大学 | 2023-05-02 | — | — | CN | claimed |
| CN-115952694-A | QAR data-based wind shear operation manipulation quality evaluation method in approach stage | 中国民用航空飞行学院 | 2023-04-11 | — | — | CN | claimed |
| CN-115617380-A | Batch generation method for updating installation package in incremental mode | 江铃汽车股份有限公司 | 2023-01-17 | — | — | CN | claimed |
| CN-114891913-A | Primer group for judging optimal application period of grape color-changing fertilizer and application of primer group | 南京农业大学 | 2022-08-12 | — | — | CN | claimed |
| CN-114584203-A | Satellite-ground link uplink data transmission method based on multi-beam satellite | 四川轻化工大学 | 2022-06-03 | — | — | CN | claimed |
| CN-114329305-A | TLE-based star link target state estimation method and system | 中国电子科技集团公司第三十八研究所 | 2022-04-12 | — | — | CN | claimed |
| CN-111523814-B | Intelligent planning method for urban rail transit schedule and vehicle bottom application plan | 西南交通大学 | 2022-02-11 | — | — | CN | claimed |
| US-20260094374-A1 | HIGH-FIDELITY 3D MESH GENERATION VIA NEURAL NETWORKS | NVIDIA CORP (US) | 2026-04-02 | — | — | US | disclosed |
| EP-4705901-A1 | SYSTEMS AND METHODS FOR EXPLORING QUANTIFIABLE TRENDS IN LINE CHARTS | Salesforce, Inc. (US) | 2026-03-11 | — | — | EP | disclosed |
| US-20260060802-A1 | AORTIC VALVE REPLACEMENT PROSTHESIS | NANJING SAINT MEDICAL TECH CO LTD (CN) | 2026-03-05 | — | — | US | disclosed |
| CN-114044473-A | Large-scale indoor installation machineshop car based on intelligence speech control | 泰州机电高等职业技术学校 | 2022-02-15 | — | — | CN | disclosed |
| CN-111523814-B | Intelligent planning method for urban rail transit schedule and vehicle bottom application plan | 西南交通大学 | 2022-02-11 | — | — | CN | disclosed |
| CN-215768914-U | Complete set of test device for iron loss test | 武汉恒盛兴电力自动化有限公司 | 2022-02-08 | — | — | CN | disclosed |
| US-11238020-B2 | Maintaining temporal associations for event data in an event database | EMC IP Holding Company LLC (US) | 2022-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260060802-A1 | AORTIC VALVE REPLACEMENT PROSTHESIS | SEM1, ATP2A1, PSMA1 | DRD2 4175/4885DRD4 4541/4885DRD3 4345/4885 |
| US-20260094374-A1 | HIGH-FIDELITY 3D MESH GENERATION VIA NEURAL NETWORKS | HTR3D, NCDN, GFRA3 | DRD2 475/4885DRD4 435/4885DRD3 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.