Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 9/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7752796 | 0.81 | ALDH1A1 (0.54) | ALDH1A1EPHX1ATMACHERAB9A | |
| SCHEMBL374983 | 0.81 | ALDH1A1 (0.54) | ALDH1A1EPHX1ATMACHERAB9A | |
| Pentadecane SCHEMBL27714673 | 0.78 | TSHR (0.55) | ALDH1A1EPHX1ATMNPSR1HPGD | |
| SCHEMBL8665886 | 0.78 | TSHR (0.35) | ALDH1A1MAPTTSHR | |
| SCHEMBL7256932 | 0.78 | ALDH1A1 (0.59) | ALDH1A1EPHX1ATMACHERAB9A | |
| SCHEMBL375532 | 0.76 | TSHR (0.56) | ALDH1A1EPHX1ATMNPSR1HPGD | |
| SCHEMBL10620372 | 0.76 | TSHR (0.56) | ALDH1A1EPHX1ATMNPSR1HPGD | |
| SCHEMBL21483476 | 0.76 | FAAH (0.43) | EPHX1ATMMAPTNPSR1TSHR | |
| SCHEMBL11210580 | 0.76 | — | — | |
| SCHEMBL11147692 | 0.75 | TRPV1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558930-A1 | NEW PROCESS FOR EARLY SACUBITRIL INTERMEDIATES | Novartis AG (CH) | 2019-10-30 | — | — | EP | disclosed |
| EP-3481799-A1 | NEW PROCESS FOR EARLY SACUBITRIL INTERMEDIATES | Novartis AG (CH) | 2019-05-15 | — | — | EP | disclosed |
| WO-2018116203-A1 | NEW PROCESS FOR EARLY SACUBITRIL INTERMEDIATES | NOVARTIS AG (CH) | 2018-06-28 | — | — | WO | disclosed |
| WO-2018007919-A1 | NEW PROCESS FOR EARLY SACUBITRIL INTERMEDIATES | NOVARTIS AG (CH) | 2018-01-11 | — | — | WO | disclosed |
| EP-2609071-A1 | NEW PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR THE MANUFACTURE NEP INHIBITORS | Novartis AG (CH) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025502-A1 | NEW PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR THE MANUFACTURE NEP INHIBITORS | NOVARTIS AG (CH) | 2012-03-01 | — | — | WO | disclosed |