Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28995960 | 0.75 | SMN1; SMN2 (0.44) | KDM4ERAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL12091521 | 0.68 | CYP2C19 (0.47) | KDM4ESMN1; SMN2HTTHPGDALDH1A1 | |
| SCHEMBL23213822 | 0.67 | HTT (0.40) | KDM4ENPC1SMN1; SMN2MAPTHTT | |
| SCHEMBL24884201 | 0.67 | SMN1; SMN2 (0.48) | KDM4ERAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL2187783 | 0.66 | SLC6A2 (0.34) | KDM4E | |
| SCHEMBL30939700 | 0.66 | GAA (0.41) | KDM4ERAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL22462979 | 0.66 | CHRM3 (0.39) | KDM4EPKM | |
| SCHEMBL16759629 | 0.65 | ALDH1A1 (0.55) | KDM4ERAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL6756428 | 0.65 | HTT (0.44) | RAB9ANPC1SMN1; SMN2MAPTHTT | |
| SCHEMBL28452003 | 0.65 | SMN1; SMN2 (0.63) | RAB9ANPC1SMN1; SMN2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693502-A | Compounds for inhibiting or degrading ITK, compositions comprising the same, methods of making the same, and methods of using the same | 纽力克斯治疗公司 | 2024-03-12 | — | — | CN | disclosed |