SCHEMBL29210595

SCHEMBL29210595

O=Cc1cc(Cl)c(Cl)cn1

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.38
FGFR4 P22455 1/20 0.35
S1PR4 O95977 2/20 0.33
TDP1 Q9NUW8 2/20 0.32
TERT O14746 1/20 0.32
KCNJ1 P48048 2/20 0.32
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
ERN1 O75460 1/20 0.30
CCR1 P32246 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29950966 0.80 TSHR (0.36) ALDH1A1S1PR4TERTERN1
SCHEMBL29952574 0.80 GAA (0.39) ALDH1A1S1PR4
SCHEMBL29426583 0.80 POLB (0.35) ALDH1A1S1PR4
SCHEMBL13233380 0.80 ERN1 (0.33) ALDH1A1S1PR4ERN1CCR1
SCHEMBL3718105 0.80 POLB (0.35) ALDH1A1S1PR4
SCHEMBL24387499 0.80 CYP3A4 (0.34) ALDH1A1S1PR4KCNJ1MEN1KMT2A
SCHEMBL336343 0.80 CYP1A2 (0.34) ALDH1A1S1PR4KCNJ1MEN1KMT2A
SCHEMBL31651981 0.77 GRIN2D (0.35) ALDH1A1S1PR4MEN1KMT2A
SCHEMBL29628445 0.76 S1PR4 (0.33) ALDH1A1S1PR4
SCHEMBL24386866 0.76 ALDH1A1 (0.40) ALDH1A1S1PR4TDP1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117986264-A Benzo nitrogen-containing polycyclic derivative regulator and preparation method and application thereof 江苏豪森药业集团有限公司 2024-05-07 CN disclosed