Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28896836 | 0.90 | SMN1; SMN2 (0.36) | SMN1; SMN2KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL28896837 | 0.87 | SMN1; SMN2 (0.37) | SMN1; SMN2KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL29211269 | 0.80 | KMT2A (0.34) | SMN1; SMN2KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL28896488 | 0.78 | SMN1; SMN2 (0.36) | SMN1; SMN2KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL28896489 | 0.76 | SMN1; SMN2 (0.37) | SMN1; SMN2KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL28896372 | 0.70 | ALDH1A1 (0.36) | SMN1; SMN2KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL1492403 | 0.70 | SMN1; SMN2 (0.54) | SMN1; SMN2KMT2AALDH1A1MEN1HTT | |
| SCHEMBL29211251 | 0.68 | SMN1; SMN2 (0.36) | SMN1; SMN2KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL28896261 | 0.68 | KDM4E (0.34) | SMN1; SMN2KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL24958271 | 0.67 | SMN1; SMN2 (0.44) | SMN1; SMN2KMT2AALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-B | 2-thio-2, 3-dihydropyrimidine-4-one derivatives, pharmaceutical compositions, preparation methods and applications thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |