Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29211269 | 0.87 | KMT2A (0.34) | KDM4ENPSR1KMT2ANUDT1SMN1; SMN2 | |
| SCHEMBL28896498 | 0.83 | SYK (0.38) | KDM4ENPSR1PLA2G2CPOLBLMNA | |
| SCHEMBL28896263 | 0.82 | SMN1; SMN2 (0.33) | KDM4EKMT2ANUDT1SMN1; SMN2POLB | |
| SCHEMBL28896836 | 0.80 | SMN1; SMN2 (0.36) | KDM4ENPSR1KMT2ASMN1; SMN2POLB | |
| SCHEMBL28896573 | 0.79 | KDM4E (0.34) | KDM4ENPSR1JAK2JAK3KMT2A | |
| SCHEMBL28896250 | 0.77 | PTGER4 (0.38) | KDM4ENPSR1JAK2JAK3KMT2A | |
| SCHEMBL28896270 | 0.74 | SMN1; SMN2 (0.38) | KDM4ENPSR1KMT2ANUDT1SMN1; SMN2 | |
| SCHEMBL24958271 | 0.72 | SMN1; SMN2 (0.44) | KDM4EKMT2ANUDT1SMN1; SMN2LMNA | |
| SCHEMBL4200796 | 0.71 | ALDH1A1 (0.45) | KDM4EKMT2ANUDT1SMN1; SMN2LMNA | |
| SCHEMBL28896575 | 0.71 | LMNA (0.33) | KDM4EKMT2ANUDT1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | disclosed |