Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 2/20 | 0.59 |
| ▸ | NOTUM | Q6P988 | 10/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133732 | 0.82 | MAPT (0.53) | PRF1MAPTCYP2E1CYP3A4CYP2A6 | |
| SCHEMBL30112100 | 0.78 | AR (0.51) | MAPTPGR | |
| SCHEMBL2241857 | 0.76 | PRF1 (0.55) | PRF1MAPTCYP2E1CYP3A4CYP2A6 | |
| SCHEMBL1133851 | 0.75 | MAPT (0.47) | PRF1MAPTCYP2E1CYP3A4CYP2A6 | |
| SCHEMBL15332488 | 0.75 | ALDH1A1 (0.45) | PRF1MAPTCYP2E1CYP3A4CYP2A6 | |
| SCHEMBL30861660 | 0.74 | KIF11 (0.63) | NOTUMCYP1A2COMTPDE3BPDE3A | |
| SCHEMBL17115582 | 0.74 | KIF11 (0.63) | NOTUMCYP1A2COMTPDE3BPDE3A | |
| SCHEMBL2698021 | 0.74 | NOTUM (0.61) | NOTUMCYP1A2COMTPDE3BPDE3A | |
| SCHEMBL1133819 | 0.73 | APP (0.54) | PRF1MAPTCYP2E1CYP3A4CYP2A6 | |
| SCHEMBL2020947 | 0.72 | PRF1 (0.55) | PRF1MAPTCYP2E1CYP3A4CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117820303-A | Tetrahydroacridine-9 carboxylic acid derivative and preparation method and application thereof | 中国药科大学 | 2024-04-05 | — | — | CN | disclosed |