SCHEMBL29216482

SCHEMBL29216482

CCOC(=O)N(C(=O)C(F)F)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.46
ALDH1A1 P00352 4/20 0.46
HSD17B10 Q99714 2/20 0.46
LMNA P02545 2/20 0.46
POLB P06746 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
MAPT P10636 2/20 0.45
CYP1A2 P05177 2/20 0.45
CYP2C9 P11712 2/20 0.45
CYP2C19 P33261 2/20 0.45
HPGD P15428 1/20 0.45
CTDSP1 Q9GZU7 1/20 0.44
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
CYP3A4 P08684 1/20 0.42
TSHR P16473 3/20 0.42
GLA P06280 1/20 0.42
PIN1 Q13526 1/20 0.41
NPC1 O15118 1/20 0.40
CHRNB2 P17787 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29216450 0.82 L3MBTL1 (0.41) ALDH1A1HSD17B10L3MBTL1MAPTHPGD
SCHEMBL29216483 0.82 ALDH1A1 (0.46) SMN1; SMN2ALDH1A1LMNAPOLBKMT2A
SCHEMBL5933087 0.82 ALDH1A1 (0.51) SMN1; SMN2ALDH1A1HSD17B10LMNAPOLB
SCHEMBL7293158 0.80 ALDH1A1 (0.49) SMN1; SMN2ALDH1A1HSD17B10LMNAPOLB
SCHEMBL5933074 0.80 ALDH1A1 (0.49) SMN1; SMN2ALDH1A1HSD17B10LMNAPOLB
SCHEMBL3781111 0.80 ALDH1A1 (0.49) SMN1; SMN2ALDH1A1HSD17B10LMNAPOLB
SCHEMBL11688083 0.79 ALDH1A1 (0.48) SMN1; SMN2ALDH1A1HSD17B10LMNAPOLB
SCHEMBL5933058 0.79 ALDH1A1 (0.48) SMN1; SMN2ALDH1A1HSD17B10LMNAPOLB
SCHEMBL5933048 0.79 ALDH1A1 (0.51) SMN1; SMN2ALDH1A1HSD17B10LMNAPOLB
SCHEMBL10869589 0.79 ALDH1A1 (0.48) SMN1; SMN2ALDH1A1HSD17B10LMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117865773-A Preparation method of difluoromethyl aromatic compound based on palladium-catalyzed decarbonylation coupling 大连理工大学 2024-04-12 CN claimed
CN-117865773-A Preparation method of difluoromethyl aromatic compound based on palladium-catalyzed decarbonylation coupling 大连理工大学 2024-04-12 CN disclosed