Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30215928 | 1.00 | MAP4K1 (0.46) | MAP4K1NR1H2NR1H3ATRKIT | |
| SCHEMBL30893064 | 0.94 | MAP4K1 (0.39) | MAP4K1ATRKITHTR6PTPN11 | |
| SCHEMBL29216559 | 0.94 | MAP4K1 (0.39) | MAP4K1ATRKITHTR6PTPN11 | |
| SCHEMBL30215951 | 0.94 | MAP4K1 (0.39) | MAP4K1ATRKITHTR6PTPN11 | |
| SCHEMBL30893067 | 0.87 | MAP4K1 (0.45) | MAP4K1NR1H2NR1H3GPR119JAK2 | |
| SCHEMBL30893070 | 0.83 | MAP4K1 (0.40) | MAP4K1ATRPTPN11GPR119JAK2 | |
| SCHEMBL29216553 | 0.82 | PTPN11 (0.45) | MAP4K1NR1H2NR1H3KITHTR6 | |
| SCHEMBL30893060 | 0.82 | PTPN11 (0.45) | MAP4K1NR1H2NR1H3KITHTR6 | |
| SCHEMBL30215942 | 0.82 | PTPN11 (0.45) | MAP4K1NR1H2NR1H3KITHTR6 | |
| SCHEMBL29608713 | 0.82 | MAP4K1 (0.49) | MAP4K1ATRHTR6PTPN11JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118043324-A | Pyrrolo [2,3-b ] pyrazine-based bifunctional compounds as HPK1 degradants and uses thereof | 百济神州有限公司 | 2024-05-14 | — | — | CN | disclosed |