Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29216559 | 1.00 | MAP4K1 (0.39) | MAP4K1GPR119ATRKITHTR6 | |
| SCHEMBL30893064 | 1.00 | MAP4K1 (0.39) | MAP4K1GPR119ATRKITHTR6 | |
| SCHEMBL30215928 | 0.94 | MAP4K1 (0.46) | MAP4K1GPR119ATRKITHTR6 | |
| SCHEMBL29216551 | 0.94 | MAP4K1 (0.46) | MAP4K1GPR119ATRKITHTR6 | |
| SCHEMBL30893070 | 0.89 | MAP4K1 (0.40) | MAP4K1GPR119ATRPTPN11 | |
| SCHEMBL30893060 | 0.88 | PTPN11 (0.45) | MAP4K1GPR119KITHTR6PTPN11 | |
| SCHEMBL29216553 | 0.88 | PTPN11 (0.45) | MAP4K1GPR119KITHTR6PTPN11 | |
| SCHEMBL30215942 | 0.88 | PTPN11 (0.45) | MAP4K1GPR119KITHTR6PTPN11 | |
| SCHEMBL24954317 | 0.85 | MAP4K1 (0.41) | MAP4K1GPR119 | |
| SCHEMBL29607752 | 0.84 | MAP4K1 (0.55) | MAP4K1ATRPTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377318-A1 | PYRROLO [2, 3-B] PYRAZINE-BASED BIFUNCTIONAL COMPOUNDS AS HPK1 DEGRADERS AND THE USE THEREOF | BeiGene, Ltd. (KY) | 2024-06-05 | — | — | EP | disclosed |
| CN-118043324-A | Pyrrolo [2,3-b ] pyrazine-based bifunctional compounds as HPK1 degradants and uses thereof | 百济神州有限公司 | 2024-05-14 | — | — | CN | disclosed |
| WO-2023006063-A1 | PYRROLO [2, 3-b] PYRAZINE-BASED BIFUNCTIONAL COMPOUNDS AS HPK1 DEGRADERS AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2023-02-02 | — | — | WO | disclosed |