Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30215942 | 1.00 | PTPN11 (0.45) | PTPN11HTR6GPR119MAP4K1NR1H2 | |
| SCHEMBL30893060 | 1.00 | PTPN11 (0.45) | PTPN11HTR6GPR119MAP4K1NR1H2 | |
| SCHEMBL30893066 | 0.89 | PTPN11 (0.42) | PTPN11MAP4K1 | |
| SCHEMBL29216559 | 0.88 | MAP4K1 (0.39) | PTPN11HTR6GPR119MAP4K1KIT | |
| SCHEMBL30215951 | 0.88 | MAP4K1 (0.39) | PTPN11HTR6GPR119MAP4K1KIT | |
| SCHEMBL30893064 | 0.88 | MAP4K1 (0.39) | PTPN11HTR6GPR119MAP4K1KIT | |
| SCHEMBL24954499 | 0.84 | GPR119 (0.37) | GPR119MAP4K1NR1H2NR1H3USP30 | |
| SCHEMBL29216551 | 0.82 | MAP4K1 (0.46) | PTPN11HTR6GPR119MAP4K1NR1H2 | |
| SCHEMBL30215928 | 0.82 | MAP4K1 (0.46) | PTPN11HTR6GPR119MAP4K1NR1H2 | |
| Hydrochloric Acid SCHEMBL30215944 | 0.82 | PTPN11 (0.48) | PTPN11HTR6MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118043324-A | Pyrrolo [2,3-b ] pyrazine-based bifunctional compounds as HPK1 degradants and uses thereof | 百济神州有限公司 | 2024-05-14 | — | — | CN | disclosed |