Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30215928 | 0.87 | MAP4K1 (0.46) | MAP4K1GPR119NR1H2NR1H3JAK2 | |
| SCHEMBL29216551 | 0.87 | MAP4K1 (0.46) | MAP4K1GPR119NR1H2NR1H3JAK2 | |
| SCHEMBL30215951 | 0.81 | MAP4K1 (0.39) | MAP4K1GPR119 | |
| SCHEMBL30893064 | 0.81 | MAP4K1 (0.39) | MAP4K1GPR119 | |
| SCHEMBL29216559 | 0.81 | MAP4K1 (0.39) | MAP4K1GPR119 | |
| SCHEMBL24954299 | 0.79 | MAP4K1 (0.70) | MAP4K1GPR119NR1H2NR1H3JAK2 | |
| SCHEMBL30215947 | 0.79 | MAP4K1 (0.70) | MAP4K1GPR119NR1H2NR1H3JAK2 | |
| SCHEMBL30893063 | 0.79 | MAP4K1 (0.70) | MAP4K1GPR119NR1H2NR1H3JAK2 | |
| SCHEMBL24954317 | 0.78 | MAP4K1 (0.41) | MAP4K1GPR119MAP3K5 | |
| SCHEMBL29930100 | 0.78 | MAP4K1 (0.53) | MAP4K1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118043324-A | Pyrrolo [2,3-b ] pyrazine-based bifunctional compounds as HPK1 degradants and uses thereof | 百济神州有限公司 | 2024-05-14 | — | — | CN | disclosed |