Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.58 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.58 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.58 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 4/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1272335 | 0.88 | PDK1 (0.53) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL11402399 | 0.86 | PDK1 (0.59) | PDK1PDK2PDK3PDK4GAA | |
| Hydrochloric Acid SCHEMBL5297660 | 0.86 | PDK1 (0.51) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL436967 | 0.86 | ALDH1A1 (0.59) | GAAALDH1A1HPGDL3MBTL1 | |
| SCHEMBL9168588 | 0.84 | ALDH1A1 (0.57) | GAAALDH1A1HPGDL3MBTL1 | |
| SCHEMBL11735899 | 0.83 | PDK1 (0.56) | PDK1PDK2PDK3PDK4GAA | |
| SCHEMBL8682011 | 0.83 | GAA (0.60) | PDK1PDK2PDK3PDK4GAA | |
| SCHEMBL10691487 | 0.82 | PDK1 (0.52) | PDK1PDK2PDK3PDK4GAA | |
| SCHEMBL14134668 | 0.81 | PDK1 (0.51) | PDK1PDK2PDK3PDK4GAA | |
| SCHEMBL3785379 | 0.81 | ALDH1A1 (0.50) | GAAALDH1A1HPGDCXCL8SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4096333-A | NITROSATION OF A 2-METHYLACETANILIDE | TENNECO CHEMICALS, INC. (US) | 1978-06-20 | — | — | US | claimed |
| US-3988347-A | NITROSATION OF A 2-METHYL-ACETANILIDE WITH SODIUM NITRITE | TENNECO CHEMICALS, INC. (US) | 1976-10-26 | — | — | US | claimed |
| US-9249145-B2 | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2016-02-02 | — | — | US | disclosed |
| US-8748432-B2 | Microbiocidal pyrazole derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2014-06-10 | — | — | US | disclosed |
| US-8748432-B2 | Microbiocidal pyrazole derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2014-06-10 | — | — | US | disclosed |
| US-8080669-B2 | Process for the synthesis of 2-aminoxazole compounds | AB SCIENCE (FR) | 2011-12-20 | — | — | US | disclosed |
| US-20110059951-A1 | HETEROCYCLIC DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION | 2011-03-10 | — | — | US | disclosed |
| EP-2019822-B1 | A NEW PROCESS FOR THE SYNTHESIS OF 2-AMINOXAZOLE COMPOUNDS | AB SCIENCE (FR) | 2010-09-08 | — | — | EP | disclosed |
| US-20090192317-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOXAZOLE COMPOUNDS | AB SCIENCE (FR) | 2009-07-30 | — | — | US | disclosed |
| US-4612395-A | Process for the production of N-(2-methyl-4-chlorophenyl)-formamidine derivatives | CIBA-GEIGY CORPORATION (US) | 1986-09-16 | — | — | US | disclosed |
| EP-0188502-A1 | ETHERIFIED 2-HYDROXY-ETHYL-PHOSPHONIC ACID DERIVATIVES AND PLANT GROWTH REGULATING AGENTS CONTAINING SAME AS ACTIVE INGREDIENT. | NITROKEMIA IPARTELEPEK (HU) | 1986-07-30 | — | — | EP | disclosed |
| EP-0187806-A1 | 2-CHLORO-ETHYL PHOSPHONIC ACID ESTERS AND PLANT GROWTH REGULATING AGENTS CONTAINING SAME AS ACTIVE INGREDIENT | NITROKEMIA IPARTELEPEK (HU) | 1986-07-23 | — | — | EP | disclosed |
| US-4600797-A | NITRATING AN AMINOBENZENE WHICH HAS A PROTECTEDD AMINO GROUP | BAYER AKTIENGESELLSCHAFT (DE) | 1986-07-15 | — | — | US | disclosed |
| WO-1986000904-A1 | ETHERIFIED 2-HYDROXY-ETHYL-PHOSPHONIC ACID DERIVATIVES AND PLANT GROWTH REGULATING AGENTS CONTAINING SAME AS ACTIVE INGREDIENT | NITROKÉMIA IPARTELEPEK (HU) | 1986-02-13 | — | — | WO | disclosed |
| WO-1986000903-A1 | 2-CHLORO-ETHYL PHOSPHONIC ACID ESTERS AND PLANT GROWTH REGULATING AGENTS CONTAINING SAME AS ACTIVE INGREDIENT | NITROKÉMIA IPARTELEPEK (HU) | 1986-02-13 | — | — | WO | disclosed |
| EP-0049711-B1 | PROCESS FOR THE PRODUCTION OF NITRO-AMINO-BENZENES | BAYER AG (DE) | 1984-02-29 | — | — | EP | disclosed |
| EP-0049711-A1 | Process for the production of nitro-amino-benzenes | BAYER AG (DE) | 1982-04-21 | — | — | EP | disclosed |
| US-4160017-A | EMETIC AGENTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-07-03 | — | — | US | disclosed |
| US-4102924-A | REACTING ACYLAMINO-ARYLS WITH HALO-ARYLS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-07-25 | — | — | US | disclosed |
| US-4096333-A | NITROSATION OF A 2-METHYLACETANILIDE | TENNECO CHEMICALS, INC. (US) | 1978-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059951-A1 | HETEROCYCLIC DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | JAK3, JAK1, JAK2 | PDK1 251/4885PDK2 184/4885PDK3 255/4885 |
| US-20090192317-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOXAZOLE COMPOUNDS | ABL1, FLT3, ABL2 | PDK1 1216/4885PDK2 863/4885PDK3 1088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.