SCHEMBL29217384

SCHEMBL29217384

O=C(Nc1cccc(Cl)c1Cl)c1ccccn1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.67
HDAC6 Q9UBN7 2/20 0.62
HDAC3 O15379 1/20 0.62
HDAC4 P56524 1/20 0.62
HDAC1 Q13547 1/20 0.62
HDAC7 Q8WUI4 1/20 0.62
HDAC2 Q92769 1/20 0.62
HDAC10 Q969S8 1/20 0.62
HDAC11 Q96DB2 1/20 0.62
HDAC8 Q9BY41 1/20 0.62
HDAC9 Q9UKV0 1/20 0.62
HDAC5 Q9UQL6 1/20 0.62
RAB9A P51151 3/20 0.61
NPC1 O15118 2/20 0.61
GRM4 Q14833 5/20 0.57
MEN1 O00255 5/20 0.57
KMT2A Q03164 5/20 0.57
LMNA P02545 2/20 0.57
MAPT P10636 2/20 0.57
MCL1 Q07820 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL20302203 0.87 MCL1 (0.69) ALDH1A1HDAC6HDAC3HDAC4HDAC1
SCHEMBL28871761 0.86 TLR7 (0.57) ALDH1A1HDAC6HDAC3HDAC4HDAC1
SCHEMBL28442197 0.84 NPC1 (0.76) ALDH1A1HDAC6HDAC3HDAC4HDAC1
SCHEMBL7989152 0.84 HDAC1 (0.77) ALDH1A1HDAC6HDAC3HDAC4HDAC1
SCHEMBL31087272 0.82 NPC1 (0.59) ALDH1A1HDAC6HDAC3HDAC4HDAC1
SCHEMBL5697349 0.81 GRM4 (0.69) ALDH1A1HDAC6HDAC3HDAC4HDAC1
SCHEMBL14082248 0.81 RAB9A (0.69) RAB9ANPC1MEN1KMT2ALMNA
SCHEMBL4522324 0.79 HDAC1 (0.69) ALDH1A1HDAC6HDAC3HDAC4HDAC1
SCHEMBL22208965 0.79 HDAC6 (0.59) HDAC6HDAC3HDAC4HDAC1HDAC7
SCHEMBL14083483 0.79 MEN1 (0.67) ALDH1A1HDAC1RAB9ANPC1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115108978-B Pyridine formylhydrazine plant antifungal medicine 西北农林科技大学 2024-05-24 CN disclosed