SCHEMBL29224613

SCHEMBL29224613

COC(=O)C(C)(C)CCCC(=O)OC(C)(C)C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 1/20 0.44
TSHR P16473 3/20 0.40
EPHX2 P34913 1/20 0.38
CYP4F2 P78329 1/20 0.36
CYP4A11 Q02928 1/20 0.36
CA2 P00918 2/20 0.33
HDAC8 Q9BY41 2/20 0.33
CA12 O43570 1/20 0.33
CA14 Q9ULX7 1/20 0.33
RECQL P46063 1/20 0.33
PTPRB P23467 1/20 0.33
STING1 Q86WV6 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
CYP2D6 P10635 1/20 0.32
CA1 P00915 1/20 0.32
CA7 P43166 1/20 0.32
HDAC1 Q13547 2/20 0.31
HDAC2 Q92769 2/20 0.31
HDAC6 Q9UBN7 2/20 0.31
HDAC3 O15379 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8433296 0.86 TSHR (0.56) TSHRCYP4F2CYP4A11CA12CA14
SCHEMBL28204859 0.81 ACLY (0.46) TSHREPHX2TDP1
SCHEMBL28887136 0.81 TSHR (0.54) TSHREPHX2CYP4F2CYP4A11CA12
SCHEMBL26109757 0.81 CYP4F2 (0.40) EPHX2CYP4F2CYP4A11
SCHEMBL28738660 0.79 TSHR (0.52) TSHREPHX2CYP4F2CYP4A11RECQL
SCHEMBL14809987 0.79 TSHR (0.52) TSHREPHX2CYP4F2CYP4A11RECQL
SCHEMBL14891456 0.79 TSHR (0.52) TSHREPHX2CYP4F2CYP4A11RECQL
SCHEMBL3280394 0.79 TSHR (0.39) DGAT1TSHRCYP4F2CYP4A11RECQL
SCHEMBL46134 0.79 TSHR (0.48) TSHRCYP4F2CYP4A11TDP1MEN1
SCHEMBL29224617 0.78 CYP4F2 (0.38) TSHREPHX2CYP4F2CYP4A11CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118146096-A 2, 2-Dimethyl-5- (4-chlorobenzyl) cyclopentanone derivative and preparation method thereof 浙江大学 2024-06-07 CN disclosed