Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.39 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29228264 | 0.93 | KIF11 (0.43) | KIF11PARP10PARP11ASIC3BACE1 | |
| SCHEMBL29228304 | 0.90 | KIF11 (0.41) | KIF11DGAT1AKR1C3 | |
| SCHEMBL28828505 | 0.89 | KIF11 (0.44) | KIF11PARP10PARP11ASIC3BACE1 | |
| SCHEMBL29228200 | 0.87 | DHODH (0.42) | BACE1SLC6A7 | |
| SCHEMBL29228377 | 0.86 | F2R (0.41) | PARP10PARP11 | |
| SCHEMBL29228244 | 0.84 | PGR (0.39) | PARP10PARP11BACE1KDM1AMAOA | |
| SCHEMBL29228300 | 0.84 | KIF11 (0.41) | KIF11DGAT1AKR1C3 | |
| SCHEMBL28828457 | 0.84 | KIF11 (0.44) | KIF11PARP10PARP11ASIC3BACE1 | |
| SCHEMBL29228198 | 0.83 | RXRA (0.41) | KIF11DGAT1AKR1C3 | |
| SCHEMBL29228440 | 0.82 | KLKB1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114746422-B | Derivatives having 1,2,3, 4-tetrahydronaphthalene moiety or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the same | 柳韩洋行 | 2024-03-12 | — | — | CN | claimed |
| CN-114746422-A | Novel derivatives having 1,2,3, 4-tetrahydronaphthalene moiety or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the same | 柳韩洋行 | 2022-07-12 | — | — | CN | claimed |
| CN-114746422-B | Derivatives having 1,2,3, 4-tetrahydronaphthalene moiety or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the same | 柳韩洋行 | 2024-03-12 | — | — | CN | disclosed |
| CN-114746422-A | Novel derivatives having 1,2,3, 4-tetrahydronaphthalene moiety or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the same | 柳韩洋行 | 2022-07-12 | — | — | CN | disclosed |