SCHEMBL29237121

SCHEMBL29237121

O=C1CCCCC1C(=O)c1cccs1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 1/20 0.59
TSHR P16473 2/20 0.49
MAPK1 P28482 1/20 0.49
HSD17B10 Q99714 1/20 0.49
HPGD P15428 4/20 0.48
RAB9A P51151 4/20 0.48
ALDH1A1 P00352 4/20 0.48
NPC1 O15118 3/20 0.48
MEN1 O00255 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C19 P33261 1/20 0.48
KMT2A Q03164 1/20 0.48
GAA P10253 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.43
CES2 O00748 1/20 0.43
CES1 P23141 1/20 0.43
DAO P14920 1/20 0.42
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7005733 0.76 TSHR (0.57) TSHRHSD17B10HPGDRAB9AALDH1A1
SCHEMBL10885557 0.76 MCL1 (0.82) MCL1MAPK1HPGDRAB9AALDH1A1
SCHEMBL9777027 0.75 RAB9A (0.58) TSHRHSD17B10HPGDRAB9AALDH1A1
SCHEMBL600072 0.75 MCL1 (1.00) MCL1MAPK1HSD17B10ALDH1A1CYP1A2
SCHEMBL5046057 0.75 RAB9A (0.58) TSHRHSD17B10HPGDRAB9AALDH1A1
SCHEMBL11844223 0.75 ALDH1A1 (0.50) TSHRHSD17B10HPGDRAB9AALDH1A1
SCHEMBL7922437 0.72 MCL1 (0.70) MCL1TSHRMAPK1ALDH1A1CYP1A2
SCHEMBL621714 0.72 ALDH1A1 (0.58) TSHRHSD17B10HPGDRAB9AALDH1A1
SCHEMBL6201220 0.71 GAA (0.54) TSHRHSD17B10HPGDRAB9AALDH1A1
SCHEMBL3858877 0.71 GAA (0.54) TSHRHSD17B10HPGDRAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117945872-A Method for synthesizing disubstituted dienone compound by catalysis of binuclear titanium complex 陕西师范大学 2024-04-30 CN disclosed