Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6225809 | 0.83 | MAPK8 (0.43) | MAPK8CYP1A2CYP2D6CYP2C19THPO | |
| SCHEMBL27383376 | 0.81 | MAPK8 (0.43) | MAPK8CYP1A2CYP2D6CYP2C19THPO | |
| SCHEMBL10386674 | 0.81 | CYP1A2 (0.46) | MAPK8CYP1A2CYP2D6CYP2C19THPO | |
| SCHEMBL3022221 | 0.79 | CTBP2 (0.57) | SMN1; SMN2CTBP2HDAC1HDAC2 | |
| SCHEMBL11202533 | 0.79 | CTBP2 (0.53) | CYP1A2IDO1LMNAPMP22SIGMAR1 | |
| SCHEMBL1052818 | 0.79 | AKR1B1 (0.58) | MAPK8CYP1A2CYP2D6CYP2C19THPO | |
| SCHEMBL3016501 | 0.78 | CTBP2 (0.54) | MAPK8RAB9ACTBP2 | |
| SCHEMBL3008052 | 0.78 | EGFR (0.48) | MAPK8RAB9AIDO1SIGMAR1 | |
| SCHEMBL2999227 | 0.78 | VNN1 (0.48) | MAPK8RAB9ASIGMAR1 | |
| SCHEMBL2648742 | 0.77 | IDO1 (0.50) | MAPK8CYP1A2CYP2D6CYP2C19THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240279220-A1 | INDOLE COMPOUNDS AND METHODS OF USE | SIONNA THERAPEUTICS INC. | 2024-08-22 | — | — | US | disclosed |
| CN-118201919-A | Indole compounds and methods of use | 健赞公司 | 2024-06-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240279220-A1 | INDOLE COMPOUNDS AND METHODS OF USE | CFTR, INMT, IDO1 | MAPK8 4129/4885CYP1A2 501/4885CYP2D6 572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.