Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29237352 | 0.83 | MAPK8 (0.43) | MAPK8CYP1A2CYP2D6CYP2C19THPO | |
| SCHEMBL3832809 | 0.81 | GLS (0.46) | MAPK8SIGMAR1 | |
| SCHEMBL6223832 | 0.81 | VNN1 (0.50) | MAPK8SIGMAR1 | |
| SCHEMBL6223798 | 0.80 | TDP1 (0.38) | SIGMAR1TDP1L3MBTL1 | |
| SCHEMBL3893395 | 0.79 | L3MBTL1 (0.51) | SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL20346346 | 0.77 | YWHAG (0.40) | MAPK8CYP1A2CYP2D6CYP2C19THPO | |
| SCHEMBL6226325 | 0.77 | MEN1 (0.51) | MAPK8CYP1A2CYP2D6CYP2C19SIGMAR1 | |
| SCHEMBL27383376 | 0.76 | MAPK8 (0.43) | MAPK8CYP1A2CYP2D6CYP2C19THPO | |
| SCHEMBL10386674 | 0.75 | CYP1A2 (0.46) | MAPK8CYP1A2CYP2D6CYP2C19THPO | |
| SCHEMBL6594686 | 0.74 | L3MBTL1 (0.50) | SMN1; SMN2TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411942-A4 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | SYNAPTIC PHARMA CORP (US) | 2005-01-26 | — | — | EP | disclosed |
| EP-1411942-A1 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | Synaptic Pharmaceutical Corporation (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003004027-A1 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2003-01-16 | — | — | WO | disclosed |