Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.38 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.38 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.38 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.38 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3965995 | 0.91 | CACNB4 (0.41) | TP53PGRCES1CACNB4CACNA1A | |
| SCHEMBL29242301 | 0.88 | BRD4 (0.43) | TP53POLBSMN1; SMN2PGRCES1 | |
| SCHEMBL30965341 | 0.88 | BRD4 (0.43) | TP53POLBSMN1; SMN2PGRCES1 | |
| SCHEMBL3969144 | 0.87 | TP53 (0.43) | TP53POLBSMN1; SMN2PGRCACNB4 | |
| SCHEMBL3966480 | 0.85 | PGR (0.38) | TP53POLBPGRCES1CACNB4 | |
| SCHEMBL30965339 | 0.85 | PGR (0.38) | TP53POLBPGRCES1CACNB4 | |
| SCHEMBL30965342 | 0.84 | MDM2 (0.48) | TP53SMN1; SMN2ALDH1A1LMNAPBRM1 | |
| SCHEMBL3967432 | 0.84 | MDM2 (0.48) | TP53SMN1; SMN2ALDH1A1LMNAPBRM1 | |
| SCHEMBL29242288 | 0.82 | PBRM1 (0.43) | TP53POLBSMN1; SMN2PGRCES1 | |
| SCHEMBL29242341 | 0.82 | HAO1 (0.42) | TP53POLBCES1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118221565-A | 3-Aryl indol-2-one compound with anticancer activity and application thereof in preparation of medicines for treating cancers | 常州大学 | 2024-06-21 | — | — | CN | disclosed |