Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 2/20 | 0.48 |
| ▸ | MDM4 | O15151 | 1/20 | 0.48 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.44 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967432 | 1.00 | MDM2 (0.48) | MDM2MDM4CDYL2CDYLMAPT | |
| SCHEMBL3964645 | 0.89 | CDYL2 (0.44) | MDM2MDM4CDYL2CDYLTP53 | |
| SCHEMBL3968668 | 0.89 | CDYL2 (0.49) | MDM2MDM4CDYL2CDYLMAPT | |
| SCHEMBL3965995 | 0.87 | CACNB4 (0.41) | MDM2TP53RAB9A | |
| SCHEMBL3968527 | 0.86 | CDYL (0.50) | MDM2CDYL2CDYLMAPTHPGD | |
| SCHEMBL29242543 | 0.84 | TP53 (0.40) | MDM2TP53SMN1; SMN2NOX1PBRM1 | |
| SCHEMBL3969144 | 0.83 | TP53 (0.43) | MDM2MAPTTP53SMN1; SMN2KDM4E | |
| SCHEMBL18025745 | 0.80 | PDE4A (0.55) | MAPTHPGDNPC1TP53MAOA | |
| SCHEMBL30965339 | 0.79 | PGR (0.38) | MAPTTP53PDE4APDE4BPDE4C | |
| SCHEMBL3966480 | 0.79 | PGR (0.38) | MAPTTP53PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118221565-A | 3-Aryl indol-2-one compound with anticancer activity and application thereof in preparation of medicines for treating cancers | 常州大学 | 2024-06-21 | — | — | CN | disclosed |