Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SLC8B1 | Q6J4K2 | 1/20 | 0.39 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.39 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29242301 | 1.00 | BRD4 (0.43) | BRD4PGRTP53MAPTTSHR | |
| SCHEMBL29242543 | 0.88 | TP53 (0.40) | PGRTP53TRPM5CES1MDM2 | |
| SCHEMBL30965336 | 0.87 | BRD4 (0.47) | BRD4TP53MAPTMEN1KMT2A | |
| SCHEMBL29242303 | 0.87 | BRD4 (0.47) | BRD4TP53MAPTMEN1KMT2A | |
| SCHEMBL30965348 | 0.85 | PGR (0.41) | BRD4PGRTP53MAPTTSHR | |
| SCHEMBL29242310 | 0.85 | PGR (0.41) | BRD4PGRTP53MAPTTSHR | |
| SCHEMBL7463659 | 0.84 | BRD4 (0.51) | BRD4PGRTP53MAPTTSHR | |
| SCHEMBL3968668 | 0.84 | CDYL2 (0.49) | BRD4PGRTP53MAPTCDYL2 | |
| SCHEMBL30965344 | 0.82 | PGR (0.41) | PGRTP53MAPTTSHRCYP1A2 | |
| SCHEMBL29242350 | 0.82 | PGR (0.41) | PGRTP53MAPTTSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118221565-A | 3-Aryl indol-2-one compound with anticancer activity and application thereof in preparation of medicines for treating cancers | 常州大学 | 2024-06-21 | — | — | CN | disclosed |