SCHEMBL292437

SCHEMBL292437

FC(F)(F)c1[c]cncc1

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.38
KMT2A Q03164 1/20 0.32
KDM5A P29375 1/20 0.30
KDM4C Q9H3R0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL604366 0.82 KIF11 (0.31) KIF11
SCHEMBL17103471 0.82 KIF11 (0.31) KIF11
SCHEMBL27949956 0.82 KIF11 (0.31) KIF11
SCHEMBL17103322 0.79
SCHEMBL2250973 0.76 KIF11 (0.37) KIF11
SCHEMBL27083514 0.73 KIF11 (0.30) KIF11
SCHEMBL9841109 0.67 SMN1; SMN2 (0.35) KIF11KMT2A
SCHEMBL27720322 0.67 KIF11 (0.59) KIF11KMT2A
SCHEMBL5011652 0.67 KIF11 (0.30) KIF11
SCHEMBL601705 0.67 KIF11 (0.30) KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 778 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240208970-A1 SUBSTITUTED HYDANTOIN COMPOUNDS, METHODS FOR PREPARATION THEREOF AND USE THEREOF IN THE TREATMENT AND/OR PREVENTION OF A CORONA VIRUS DISEASE CARLSSON JENS (SE) 2024-06-27 US claimed
WO-2024118801-A1 LINEAR HETEROARYL DIAMIDE IRE1/XBP1S ACTIVATORS PROTEGO BIOPHARMA, INC. (US) 2024-06-06 WO claimed
EP-4373825-A1 NITRILE SUMO INHIBITORS AND USES THEREOF Suvalent Therapeutics, Inc. (US) 2024-05-29 EP claimed
CN-117751105-A Substituted hydantoin compounds, process for their preparation and their use in the treatment and/or prophylaxis of coronavirus diseases J·卡尔松 2024-03-22 CN claimed
US-20240091303-A1 BIOMARKER-BASED TREATMENT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS AND DIABETIC KIDNEY DISEASE GOLDFINCH BIO, INC. 2024-03-21 US claimed
EP-4329883-A1 SUBSTITUTED HYDANTOIN COMPOUNDS, METHODS FOR PREPARATION THEREOF AND USE THEREOF IN THE TREATMENT AND/OR PREVENTION OF A CORONA VIRUS DISEASE Carlsson, Jens (SE) 2024-03-06 EP claimed
EP-3852533-B1 PYRIDAZINONES AND METHODS OF USE THEREOF GOLDFINCH BIO INC (US) 2024-02-28 EP claimed
US-20230303584-A1 4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE SUMO INHIBITORS AND USES THEREOF CIT THERAPEUTICS LLC 2023-09-28 US claimed
CN-111566109-B 2,4,6, 7-tetrahydropyrazolo [4,3-d ] pyrimidin-5-one derivatives and related compounds for the treatment of vasculitis and inflammatory diseases 爱杜西亚药品有限公司 2023-07-11 CN claimed
CN-116283773-A Sinomenine amide derivative, and preparation method and application thereof 安徽农业大学 2023-06-23 CN claimed
WO-2002022583-A2 PYRIDINYL AMIDES AND IMIDES FOR USE AS FUNGICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2002-03-21 WO claimed
US-6300357-B1 FOR THERAPY OF MYCOTIC DISEASE OF A HUMAN BEING AND AN ANIMAL SANKYO COMPANY, LIMITED (JP) 2001-10-09 US claimed
EP-1114028-A1 AZA-BICYCLES WHICH MODULATE THE INHIBITION OF CELL ADHESION Aventis Pharma Limited (GB) 2001-07-11 EP claimed
EP-1056728-A1 DIHYDRO-BENZO(1,4)OXAZINES AND TETRAHYDROQUINOXALINES Aventis Pharma Limited (GB) 2000-12-06 EP claimed
WO-2000039103-B1 DIHYDRO-BENZO(1,4)OXAZINES AND TETRAHYDROQUINOXALINES AVENTIS PHARMA LTD (GB) 2000-09-28 WO claimed
US-6117821-A COMPRISING HERBICIDES AND AGRONOMICALLY ACCEPTABLE CARRIERS; USE THEREOF AS BROAD SPECTRUM HERBICIDES WHICH ARE EFFECTIVE AGAINST BOTH MONOCOT AND DICOT WEED SPECIES IN BOTH PREEMERGENCE AND POSTEMERGENCE APPLICATIONS ROHM AND HAAS COMPANY (US) 2000-09-12 US claimed
WO-2000039103-A1 DIHYDRO-BENZO(1,4)OXAZINES AND TETRAHYDROQUINOXALINES AVENTIS PHARMA LIMITED (GB) 2000-07-06 WO claimed
WO-2000015612-A1 AZA-BICYCLES WHICH MODULATE THE INHIBITION OF CELL ADHESION AVENTIS PHARMA LIMITED (GB) 2000-03-23 WO claimed
EP-0185256-B1 TRIAZOLE DERIVATES, THEIR PREPARATION AND THEIR USE AS PESTICIDES CIBA-GEIGY AG (CH) 1991-01-30 EP claimed
EP-0185256-A2 Triazole derivates, their preparation and their use as pesticides CIBA-GEIGY AG (CH) 1986-06-25 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230303584-A1 4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE SUMO INHIBITORS AND USES THEREOF SUMO1, SUMO3, SUMO2 KIF11 3377/4885KMT2A 1174/4885KDM5A 468/4885
US-20240091303-A1 BIOMARKER-BASED TREATMENT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS AND DIABETIC KIDNEY DISEASE TRPC5, REN, SLC5A1 KIF11 2547/4885KMT2A 4776/4885KDM5A 2617/4885
US-20240208970-A1 SUBSTITUTED HYDANTOIN COMPOUNDS, METHODS FOR PREPARATION THEREOF AND USE THEREOF IN THE TREATMENT AND/OR PREVENTION OF A CORONA VIRUS DISEASE FURIN, ACE, PEPD KIF11 4841/4885KMT2A 726/4885KDM5A 1346/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.