Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29245343 | 1.00 | USP30 (0.37) | USP30PARP1HPGDSHRH3RIPK2 | |
| SCHEMBL25240426 | 0.87 | USP30 (0.38) | USP30PARP1HPGDSRIPK2GPR119 | |
| SCHEMBL31362193 | 0.87 | USP30 (0.38) | USP30PARP1HPGDSRIPK2GPR119 | |
| SCHEMBL29245339 | 0.79 | PRKAA2 (0.42) | USP30GPR119 | |
| SCHEMBL25604880 | 0.79 | PARP1 (0.38) | USP30PARP1HPGDSHRH3RIPK2 | |
| SCHEMBL29245338 | 0.79 | PRKAA2 (0.42) | USP30GPR119 | |
| Hydrochloric Acid SCHEMBL25240102 | 0.78 | PARP1 (0.38) | USP30PARP1HPGDSHRH3RIPK2 | |
| SCHEMBL25288422 | 0.76 | HPGDS (0.35) | USP30PARP1HPGDSHRH3RIPK2 | |
| SCHEMBL25192651 | 0.73 | GPR119 (0.35) | USP30GPR119 | |
| SCHEMBL30234728 | 0.73 | GPR119 (0.35) | USP30GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118019532-A | Azetidine and pyrrolidine PARP1 inhibitors and uses thereof | 新特拉有限公司 | 2024-05-10 | — | — | CN | disclosed |