Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 8/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2926155 | 0.93 | HDAC7 (0.43) | HCRTR2HCRTR1HDAC7CHRM3CYP46A1 | |
| SCHEMBL2925064 | 0.92 | HCRTR2 (0.43) | HCRTR2HCRTR1CHRM3GRM5 | |
| SCHEMBL2930272 | 0.92 | CHRM1 (0.46) | HCRTR2HCRTR1CHRM1CHRM3GRM5 | |
| SCHEMBL2929505 | 0.92 | HCRTR2 (0.43) | HCRTR2HCRTR1CHRM3GRM5 | |
| SCHEMBL2926961 | 0.92 | MEN1 (0.43) | HCRTR2HCRTR1MEN1ALDH1A1KMT2A | |
| SCHEMBL3414068 | 0.92 | MEN1 (0.43) | HCRTR2HCRTR1MEN1ALDH1A1KMT2A | |
| SCHEMBL2929944 | 0.92 | HCRTR1 (0.39) | HCRTR2HCRTR1CHRM1CYP46A1 | |
| SCHEMBL2925883 | 0.90 | CHRM1 (0.33) | HCRTR2HCRTR1CHRM1HDAC7CYP46A1 | |
| SCHEMBL2931139 | 0.90 | HCRTR1 (0.39) | HCRTR2HCRTR1 | |
| SCHEMBL2924236 | 0.90 | KDM1A (0.35) | HCRTR2HCRTR1HDAC7CYP46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | claimed |
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |