Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 11/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 11/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | ABL2 | P42684 | 2/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CPS1 | P31327 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931530 | 0.93 | HCRTR1 (0.46) | HCRTR1HCRTR2ABL1EGFRSRC | |
| SCHEMBL2924875 | 0.90 | HCRTR2 (0.37) | HCRTR1HCRTR2 | |
| SCHEMBL2929170 | 0.89 | KDM4E (0.43) | HCRTR1HCRTR2ABL1EGFRSRC | |
| SCHEMBL2929133 | 0.89 | HCRTR1 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL2926155 | 0.87 | HDAC7 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL2930272 | 0.87 | CHRM1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL2929505 | 0.87 | HCRTR2 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL2925064 | 0.87 | HCRTR2 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL2931138 | 0.86 | HCRTR1 (0.40) | HCRTR1HCRTR2MAOBNPC1CPS1 | |
| SCHEMBL2925883 | 0.85 | CHRM1 (0.33) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | claimed |
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |