Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 2/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | KRAS | P01116 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.31 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924875 | 0.90 | HCRTR2 (0.37) | CHRM1HCRTR2HCRTR1HDAC7CYP46A1 | |
| SCHEMBL2926155 | 0.87 | HDAC7 (0.43) | HCRTR2HCRTR1HDAC7CYP46A1 | |
| SCHEMBL2929505 | 0.87 | HCRTR2 (0.43) | HCRTR2HCRTR1 | |
| SCHEMBL2925064 | 0.87 | HCRTR2 (0.43) | HCRTR2HCRTR1 | |
| SCHEMBL2930272 | 0.87 | CHRM1 (0.46) | CHRM1HCRTR2HCRTR1 | |
| SCHEMBL2925882 | 0.86 | RXRA (0.33) | CHRM1PDE10ARXRARXRBRXRG | |
| SCHEMBL2931139 | 0.85 | HCRTR1 (0.39) | HCRTR2HCRTR1 | |
| SCHEMBL2924236 | 0.85 | KDM1A (0.35) | HCRTR2HCRTR1HDAC7CYP46A1 | |
| SCHEMBL2933414 | 0.84 | HCRTR1 (0.38) | HCRTR2HCRTR1 | |
| SCHEMBL2926961 | 0.82 | MEN1 (0.43) | HCRTR2HCRTR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |