Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.79 |
| ▸ | MAPT | P10636 | 6/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.76 |
| ▸ | MEN1 | O00255 | 4/20 | 0.76 |
| ▸ | TP53 | P04637 | 5/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2926391 | 0.89 | TP53 (0.79) | RAB9AMAPTKMT2AMEN1TP53 | |
| SCHEMBL2930341 | 0.89 | KMT2A (0.73) | RAB9AMAPTKMT2AMEN1TP53 | |
| SCHEMBL2928891 | 0.88 | KMT2A (0.84) | RAB9AMAPTKMT2AMEN1TP53 | |
| SCHEMBL2922419 | 0.88 | RAB9A (1.00) | RAB9AMAPTKMT2AMEN1TP53 | |
| SCHEMBL2928399 | 0.88 | KMT2A (0.69) | RAB9AMAPTKMT2AMEN1TP53 | |
| SCHEMBL2923933 | 0.87 | RAB9A (0.74) | RAB9AMAPTKMT2AMEN1TP53 | |
| SCHEMBL2928990 | 0.86 | KMT2A (1.00) | RAB9AMAPTKMT2AMEN1TP53 | |
| SCHEMBL2930509 | 0.85 | KMT2A (0.79) | RAB9AMAPTKMT2AMEN1TP53 | |
| SCHEMBL2929006 | 0.83 | KMT2A (0.68) | RAB9AMAPTKMT2AMEN1TP53 | |
| SCHEMBL2930743 | 0.82 | KMT2A (0.67) | RAB9AMAPTKMT2AMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431602-B2 | Beta-amino acid derivatives for treatment of diabetes | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-04-30 | — | — | US | claimed |
| EP-2231640-B1 | BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2012-06-06 | — | — | EP | claimed |
| US-20100331346-A1 | BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-12-30 | — | — | US | claimed |
| EP-2231640-A1 | BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES | Merck Patent GmbH (DE) | 2010-09-29 | — | — | EP | claimed |
| WO-2009092432-A1 | BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2009-07-30 | — | — | WO | claimed |
| US-8431602-B2 | Beta-amino acid derivatives for treatment of diabetes | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-04-30 | — | — | US | disclosed |
| EP-2231640-B1 | BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2012-06-06 | — | — | EP | disclosed |
| US-20100331346-A1 | BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-12-30 | — | — | US | disclosed |
| EP-2231640-A1 | BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES | Merck Patent GmbH (DE) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009092432-A1 | BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331346-A1 | BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES | GPR119, GLS, GCKR | RAB9A 2655/4885MAPT 3056/4885KMT2A 3191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.