Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | KRAS | P01116 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924872 | 0.90 | HDAC7 (0.36) | HDAC7HCRTR1HCRTR2CHRM1POLB | |
| SCHEMBL2926153 | 0.87 | HDAC7 (0.44) | HDAC7HCRTR1HCRTR2POLB | |
| SCHEMBL2925061 | 0.86 | HCRTR2 (0.41) | HCRTR1HCRTR2 | |
| SCHEMBL2930271 | 0.86 | CHRM1 (0.44) | HCRTR1HCRTR2CHRM1 | |
| SCHEMBL2925883 | 0.86 | CHRM1 (0.33) | RXRARXRBRXRGHDAC7HCRTR1 | |
| SCHEMBL2931138 | 0.85 | HCRTR1 (0.40) | HCRTR1HCRTR2PIK3CA | |
| SCHEMBL2924235 | 0.85 | POLB (0.39) | HDAC7HCRTR1HCRTR2POLBPIK3CA | |
| SCHEMBL2933413 | 0.84 | RORB (0.38) | HCRTR1HCRTR2JAK2TRPV1 | |
| SCHEMBL3416131 | 0.82 | CDK4 (0.41) | HCRTR1HCRTR2 | |
| SCHEMBL2926957 | 0.82 | CDK4 (0.41) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |