Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 7/20 | 0.73 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.73 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.73 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.73 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.73 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.73 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.73 |
| ▸ | GABRP | O00591 | 2/20 | 0.73 |
| ▸ | GABRD | O14764 | 2/20 | 0.73 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.73 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.73 |
| ▸ | GABRE | P78334 | 2/20 | 0.73 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.73 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.73 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.73 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.73 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.73 |
| ▸ | ALB | P02768 | 1/20 | 0.73 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.73 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5038242 | 0.87 | GABRA1 (0.62) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL24194446 | 0.85 | GABRA1 (0.74) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL11681384 | 0.84 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2928346 | 0.84 | GABRA1 (0.73) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL9278054 | 0.84 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL29362687 | 0.84 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL1019217 | 0.84 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL21442 | 0.84 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL29360474 | 0.84 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL4817228 | 0.84 | GABRA1 (0.73) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231623-B1 | 5-PHENYL-1H-BENZO[E][1, 4]DIAZEPINE COMPOUNDS SUBSTITUTED WITH AN HYDROXAMIC ACID GROUP AS HISTONE DEACETYLASE INHIBITORS | UNIV FIRENZE (IT) | 2013-05-22 | — | — | EP | disclosed |
| EP-2231623-B1 | 5-PHENYL-1H-BENZO[E][1, 4]DIAZEPINE COMPOUNDS SUBSTITUTED WITH AN HYDROXAMIC ACID GROUP AS HISTONE DEACETYLASE INHIBITORS | UNIV FIRENZE (IT) | 2013-05-22 | — | — | EP | disclosed |
| US-8324202-B2 | 5-phenyl-1H-benzo [E] [1,4] diazepine compounds substituted with an hydroxamic acid group as histone deacetylase inhibitors | UNIVERSITA DEGLI STUDI DI FIRENZE (IT) | 2012-12-04 | — | — | US | disclosed |
| US-20100331316-A1 | 5-PHENYL-LH-BENZ0 [E] [1,4] DIAZEPINE COMPOUNDS SUBSTITUTED WITH AN HYDROXAMIC ACID GROUP AS HISTONE DEACETYLASE INHIBITORS | A.I.L. FIRENZE SEZIONE AUTONOMA DI FIRENZE DELL'ASSOCIAZIONE ITALIANA CONTRO LE LEUCEMIE, LINFOMI E MIELOMA - ONLUS (IT) | 2010-12-30 | — | — | US | disclosed |
| EP-2231623-A1 | 5-PHENYL-LH-BENZ0 [E] [1, 4] DIAZEPINE COMPOUNDS SUBSTITUTED WITH AN HYDROXAMIC ACID GROUP AS HISTONE DEACETYLASE INHIBITORS | Universita' Degli Studi di Firenze (IT) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009081349-A1 | 5-PHENYL-LH-BENZ0 [E] [1, 4] DIAZEPINE COMPOUNDS SUBSTITUTED WITH AN HYDROXAMIC ACID GROUP AS HISTONE DEACETYLASE INHIBITORS | UNIVERSITA' DEGLI STUDI DI FIRENZE (IT) | 2009-07-02 | — | — | WO | disclosed |
| EP-0264797-B1 | Benzodiazepines assay, tracers, immunogens and antibodies | ABBOTT LAB (US) | 1996-01-10 | — | — | EP | disclosed |
| EP-0264797-A2 | Benzodiazepines assay, tracers, immunogens and antibodies | ABBOTT LABORATORIES (US) | 1988-04-27 | — | — | EP | disclosed |
| EP-0033973-B1 | BENZODIAZEPINE DERIVATIVES, INTERMEDIATES AND PROCESSES FOR PREPARING THEM, THEIR USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-09-28 | — | — | EP | disclosed |
| US-4361511-A | ANTIALDOSTERONES | HOFFMANN-LA ROCHE INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0033973-A1 | Benzodiazepine derivatives, intermediates and processes for preparing them, their use and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-08-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331316-A1 | 5-PHENYL-LH-BENZ0 [E] [1,4] DIAZEPINE COMPOUNDS SUBSTITUTED WITH AN HYDROXAMIC ACID GROUP AS HISTONE DEACETYLASE INHIBITORS | HDAC10, HDAC1, HDAC5 | GABRA1 2012/4885GABRG2 1967/4885GABRB3 1869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.