Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Diazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 8/20 | 1.00 |
| ▸ | GABRG2 known ✓ | P18507 | 8/20 | 1.00 |
| ▸ | GABRB3 known ✓ | P28472 | 8/20 | 1.00 |
| ▸ | GABRA5 known ✓ | P31644 | 8/20 | 1.00 |
| ▸ | GABRA3 known ✓ | P34903 | 8/20 | 1.00 |
| ▸ | GABRA2 known ✓ | P47869 | 8/20 | 1.00 |
| ▸ | GABRB2 known ✓ | P47870 | 5/20 | 1.00 |
| ▸ | GABRP known ✓ | O00591 | 2/20 | 1.00 |
| ▸ | GABRD known ✓ | O14764 | 2/20 | 1.00 |
| ▸ | GABRB1 known ✓ | P18505 | 2/20 | 1.00 |
| ▸ | GABRA4 known ✓ | P48169 | 2/20 | 1.00 |
| ▸ | GABRE known ✓ | P78334 | 2/20 | 1.00 |
| ▸ | GABRA6 known ✓ | Q16445 | 2/20 | 1.00 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 2/20 | 1.00 |
| ▸ | GABRG3 known ✓ | Q99928 | 2/20 | 1.00 |
| ▸ | GABRQ known ✓ | Q9UN88 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 4/20 | 1.00 |
| ▸ | CACNA1F | O60840 | 1/20 | 1.00 |
| ▸ | ALB | P02768 | 1/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diazepam SCHEMBL16922183 | 1.00 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL9278054 | 1.00 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL29362687 | 1.00 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL1019217 | 1.00 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL3043280 | 0.99 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL11345350 | 0.99 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL6298785 | 0.99 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL6014348 | 0.99 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL17555369 | 0.99 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL4370625 | 0.99 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 99400 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-122072257-A | Method for rapidly detecting poison in blood | 中国科学院大连化学物理研究所 | 2026-05-22 | — | — | CN | claimed |
| US-20260143961-A1 | ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES | UNIVERSAL DISPLAY CORPORATION (US) | 2026-05-21 | — | — | US | claimed |
| CN-122070278-A | Bifunctional protein degradation agent containing aryl substituted heteroaryl and application thereof | 标新生物医药科技(上海)有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122046260-A | Closed-loop audio and video personalized recommendation method and system based on multi-mode brain signals | 华南理工大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122044840-A | Cluster joint scheduling method and system for multi-task workflow | 杉湖智算科技(湖南)有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122035018-A | Method for adjusting the response of an advanced driver assistance system | 通用汽车环球科技运作有限责任公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122046734-A | Task reliability assessment method for equipment system based on task chain element model | 西北工业大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122031711-A | Anti-epileptic polypeptide coupled drug and preparation method and application thereof | 国家纳米科学中心 | 2026-05-15 | — | — | CN | claimed |
| US-20260131780-A1 | METHOD FOR ADAPTING RESPONSES OF AN ADVANCED DRIVER ASSISTANCE SYSTEM | GM GLOBAL TECH OPERATIONS LLC (US) | 2026-05-14 | — | — | US | claimed |
| US-4088756-A | TREATING PSORIASIS, DERMATITIS WITH ADRENERGIC AGENTS AND HYPOGLYCEMIC AGENTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1978-05-09 | — | — | US | claimed |
| US-4083948-A | IODINE LABELS | HOFFMANN-LA ROCHE, INC. (US) | 1978-04-11 | — | — | US | claimed |
| US-4080902-A | LINEARLY ENCAPSULATED EXPLOSIVE WITH METAL CLADDED PYROTECHNIC MATERIAL AROUND ENCAPSULATION | TELEDYNE MCCORMICK SELPH (US) | 1978-03-28 | — | — | US | claimed |
| US-4054859-A | Flame probe | ROBERTSHAW CONTROLS COMPANY (US) | 1977-10-18 | — | — | US | claimed |
| US-4044003-A | Process for preparing 1,4-benzodiazepines | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-08-23 | — | — | US | claimed |
| US-4036228-A | Osmotic dispenser with gas generating means | ALZA CORPORATION (US) | 1977-07-19 | — | — | US | claimed |
| US-4028467-A | Analgesic compositions comprising levo-propoxyphene and benzo diazepine and process | BERGER FRANK M | 1977-06-07 | — | — | US | claimed |
| US-3981398-A | Aid in the management of clinical emergencies in medical and dental practices and other circumstances | Pienaar, Hendrik Lukas (ZA) | 1976-09-21 | — | — | US | claimed |
| US-3965255-A | DRUG ENCAPSULATED IN OR COATED WITH A SOLVENT MEMBRANE | E. E. ELJIM ECOLOGY LTD. (IL) | 1976-06-22 | — | — | US | claimed |
| US-3960757-A | HYDROPHOBIC | TOYO JOZO CO., LTD. (JA) | 1976-06-01 | — | — | US | claimed |