Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 4/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29259413 | 1.00 | GPR183 (0.62) | GPR183KCNH2HPGDALDH1A1L3MBTL1 | |
| SCHEMBL26487595 | 0.87 | GPR183 (0.73) | GPR183KCNH2HPGDALDH1A1L3MBTL1 | |
| SCHEMBL29259411 | 0.82 | ALDH1A1 (0.54) | GPR183HPGDALDH1A1L3MBTL1CA12 | |
| SCHEMBL20631562 | 0.79 | HPGD (0.86) | GPR183HPGDALDH1A1L3MBTL1CA12 | |
| SCHEMBL16598585 | 0.77 | GPR183 (1.00) | GPR183KCNH2 | |
| SCHEMBL16598583 | 0.77 | GPR183 (1.00) | GPR183KCNH2 | |
| SCHEMBL29259402 | 0.76 | HPGD (0.69) | GPR183HPGDALDH1A1L3MBTL1CA12 | |
| SCHEMBL26093881 | 0.74 | GPR183 (0.93) | GPR183KCNH2 | |
| SCHEMBL10053023 | 0.73 | HPGD (0.75) | GPR183HPGDALDH1A1L3MBTL1CA12 | |
| SCHEMBL28474010 | 0.73 | HPGD (0.75) | GPR183HPGDALDH1A1L3MBTL1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118201911-A | Compounds and their use as GPR183 inhibitors | 南京艾美斐生物医药科技有限公司 | 2024-06-14 | — | — | CN | claimed |
| CN-118201911-A | Compounds and their use as GPR183 inhibitors | 南京艾美斐生物医药科技有限公司 | 2024-06-14 | — | — | CN | disclosed |