Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 3/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.33 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1339085 | 0.83 | ADORA2B (0.36) | ADORA2B | |
| SCHEMBL388918 | 0.78 | AAK1 (0.38) | METAP1SYKLCKHSP90AA1HSP90AB1 | |
| SCHEMBL2881436 | 0.76 | GLS (0.37) | ADORA2B | |
| SCHEMBL30365682 | 0.74 | ADORA3 (0.41) | METAP1SYKBRD9CYP17A1ADORA2B | |
| SCHEMBL6644306 | 0.72 | BRD9 (0.40) | METAP1SYKBRD9RXFP1CYP17A1 | |
| SCHEMBL17336530 | 0.72 | AAK1 (0.42) | METAP1SYKBRD9RXFP1LCK | |
| SCHEMBL14032205 | 0.71 | ATR (0.48) | METAP1SYKBRD9RXFP1CYP17A1 | |
| SCHEMBL25297301 | 0.71 | ATR (0.41) | METAP1SYKBRD9RXFP1LCK | |
| SCHEMBL15583603 | 0.71 | AAK1 (0.41) | METAP1SYKBRD9RXFP1LCK | |
| SCHEMBL594117 | 0.71 | CYP17A1 (0.40) | METAP1SYKBRD9RXFP1CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125793-B1 | IMIDAZOLIDINONYL AMINOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2010-09-01 | — | — | EP | disclosed |