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SCHEMBL29265441

SCHEMBL29265441

CCOC(=O)CN(C(=O)c1ccc(F)cc1)c1cccc(C(=O)Nc2c(Br)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2OC(F)F)c1F

nearest known ligand 0.32

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.32
▸ LMNA P02545 1/20 0.32
▸ HTT P42858 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ F2R P25116 1/20 0.31
▸ KMT2A Q03164 4/20 0.31
▸ MEN1 O00255 3/20 0.31
▸ MAPT P10636 2/20 0.31
▸ TSHR P16473 1/20 0.31
▸ RAB9A P51151 1/20 0.31
▸ DHODH Q02127 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18354530 0.91 HTT (0.34) HTTSMN1; SMN2F2RKMT2AMEN1
SCHEMBL29265447 0.90 MAPK1 (0.34) LMNASMN1; SMN2KMT2AMEN1MAPT
SCHEMBL18354409 0.88 DHODH (0.33) LMNAHTTSMN1; SMN2KMT2AMEN1
SCHEMBL31348940 0.87 HTT (0.36) KDM4EHTTSMN1; SMN2KMT2AMEN1
SCHEMBL18354645 0.86 HDAC8 (0.34) LMNASMN1; SMN2DHODH
SCHEMBL18354046 0.86 TSHR (0.35) KMT2AMEN1TSHRDHODH
SCHEMBL22402095 0.86 HTT (0.36) KDM4EHTTSMN1; SMN2KMT2AMEN1
SCHEMBL23264274 0.86 PDE4B (0.35) HTTSMN1; SMN2
SCHEMBL29431922 0.86 PDE4B (0.35) HTTSMN1; SMN2
SCHEMBL18354651 0.85 MAPT (0.34) LMNAHTTSMN1; SMN2KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118026883-A Amide compound and preparation method and application thereof 南通泰禾化工股份有限公司 2024-05-14 — — CN disclosed