Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | F2R | P25116 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18354409 | 0.95 | DHODH (0.33) | HTTSMN1; SMN2DHODHTSHRHDAC8 | |
| SCHEMBL18354645 | 0.95 | HDAC8 (0.34) | SMN1; SMN2DHODHHDAC8SCN8ASCN10A | |
| SCHEMBL18354046 | 0.95 | TSHR (0.35) | DHODHTSHRHDAC8MEN1KMT2A | |
| SCHEMBL16863522 | 0.92 | MLYCD (0.36) | DHODHTSHRHDAC8 | |
| SCHEMBL18354651 | 0.92 | MAPT (0.34) | HTTSMN1; SMN2DHODHTSHRHDAC8 | |
| SCHEMBL18354633 | 0.92 | MLYCD (0.39) | DHODHHDAC8 | |
| SCHEMBL18354411 | 0.92 | HDAC8 (0.35) | DHODHTSHRHDAC8 | |
| SCHEMBL18354535 | 0.92 | TSHR (0.33) | DHODHTSHRSCN8ASCN10AF2R | |
| SCHEMBL18354043 | 0.91 | ALDH1A1 (0.35) | HTTSMN1; SMN2DHODHHDAC8MEN1 | |
| SCHEMBL29265441 | 0.91 | KDM4E (0.32) | HTTSMN1; SMN2DHODHTSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210051955-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2021-02-25 | — | — | US | disclosed |
| US-20180077930-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-03-22 | — | — | US | disclosed |
| US-20180077930-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-03-22 | — | — | US | disclosed |
| US-9839216-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2017-12-12 | — | — | US | disclosed |
| US-9839216-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2017-12-12 | — | — | US | disclosed |
| US-20170000120-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2017-01-05 | — | — | US | disclosed |
| US-20170000120-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2017-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180077930-A1 | INSECTICIDAL COMPOUNDS | ACHE, CYP4X1, ITPR3 | HTT 3063/4885SMN1; SMN2 1665/4885DHODH 3024/4885 |
| US-20210051955-A1 | INSECTICIDAL COMPOUNDS | ACHE, CYP4X1, ITPR3 | HTT 3063/4885SMN1; SMN2 1665/4885DHODH 3024/4885 |
| US-20170000120-A1 | INSECTICIDAL COMPOUNDS | ACHE, HDAC6, TUBA3C | HTT 2680/4885SMN1; SMN2 1416/4885DHODH 3226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.