Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CPA1 | P15085 | 2/20 | 0.45 |
| ▸ | CPA2 | P48052 | 2/20 | 0.45 |
| ▸ | CPA4 | Q9UI42 | 2/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | NPR3 | P17342 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29269490 | 1.00 | CTSK (0.50) | CTSKCTSSMEN1ALDH1A1HPGD | |
| SCHEMBL29269418 | 0.90 | CTSS (0.53) | CTSKCTSSMEN1ALDH1A1HPGD | |
| SCHEMBL29269425 | 0.90 | CTSS (0.53) | CTSKCTSSMEN1ALDH1A1HPGD | |
| SCHEMBL31214776 | 0.82 | GNPAT (0.60) | CTSKCTSSMEN1ALDH1A1HPGD | |
| SCHEMBL31294616 | 0.81 | SYK (0.55) | CTSKCTSSCTSL | |
| SCHEMBL7015253 | 0.81 | SYK (0.55) | CTSKCTSSCTSL | |
| SCHEMBL30902868 | 0.80 | CTSK (0.51) | CTSKCTSSCTSL | |
| SCHEMBL29269435 | 0.80 | CTSL (0.53) | CTSKCTSSCTSL | |
| SCHEMBL29269432 | 0.80 | CTSL (0.53) | CTSKCTSSCTSL | |
| SCHEMBL29051019 | 0.79 | CTSS (0.57) | CTSKCTSSCTSLNOD2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118251383-A | Macrocyclic compounds as proteasome beta subunit type 5 inhibitors | 利德探索中心有限公司 | 2024-06-25 | — | — | CN | disclosed |
| EP-4301736-A1 | MACROCYCLIC COMPOUNDS AS PROTEASOME SUBUNIT BETA TYPE-5 INHIBITORS | Lead Discovery Center GmbH (DE) | 2024-01-10 | — | — | EP | disclosed |
| WO-2023046939-A1 | MACROCYCLIC COMPOUNDS AS PROTEASOME SUBUNIT BETA TYPE-5 INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2023-03-30 | — | — | WO | disclosed |