Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP14 | Q460N5 | 14/20 | 0.39 |
| ▸ | PTGES | O14684 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29270728 | 0.93 | PARP14 (0.40) | PARP14 | |
| SCHEMBL29270729 | 0.89 | PARP14 (0.38) | PARP14TP53MAPTTHRBSMN1; SMN2 | |
| SCHEMBL29270781 | 0.83 | TP53 (0.37) | TP53MAPTSMN1; SMN2 | |
| SCHEMBL29270692 | 0.81 | AGTR1 (0.36) | TP53 | |
| SCHEMBL29270810 | 0.80 | TP53 (0.35) | TP53MAPTSMN1; SMN2 | |
| SCHEMBL29270804 | 0.80 | TP53 (0.32) | TP53MAPTSMN1; SMN2 | |
| SCHEMBL29270759 | 0.79 | TP53 (0.32) | TP53MAPTSMN1; SMN2 | |
| SCHEMBL29270744 | 0.79 | TP53 (0.34) | TP53MAPTSMN1; SMN2 | |
| SCHEMBL29270772 | 0.78 | TP53 (0.35) | TP53MAPTSMN1; SMN2 | |
| SCHEMBL29270828 | 0.78 | TP53 (0.34) | TP53MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116964048-A | Bicyclic tetrahydroazepine derivatives for the treatment of cancer | 豪夫迈·罗氏有限公司 | 2023-10-27 | — | — | CN | disclosed |